_id Year Country ConditionGroup ConditionSubgroup SpecificCondition LiveBirth SpontaneousStillbirth SpontaneousLateFetalLoss TOPFA Total TotalBirthsPopulation TBP TBPLCI TBPUCI TotalGen TotalGenPrevalence TotalGenPrevalence95LowCi TotalGenPrevalence95UpCi TotalExcludingKnownGeneticConditions TBPExcludingKnownGeneticConditions TBPExcludingKnownGeneticConditionsLCI TBPExcludingKnownGeneticConditionsUCI LiveBirthsPopulation LBP LBPLCI LBPUCI LiveGen LiveGenPrevalence LiveGenPrevalence95LowCi LiveGenPrevalence95UpCi LiveNonGen LiveNonGenPrevalence LiveNonGenPrevalence95LowCi LiveNonGenPrevalence95UpCi TotalBirthPopulation LiveBirthPopulation 1 2024 S92000003 All conditions All conditions All conditions 772 9 3 318 1102 46065 239.2 225.3 253.8 313 67.9 60.6 75.9 789 171.3 159.5 183.7 45909 168.2 156.5 180.4 136 29.6 24.9 35 636 138.5 128 149.7 46065 45909 2 2024 S92000003 Nervous system conditions Nervous system conditions Nervous system conditions 43 0 0 89 132 46065 28.7 24 34 21 4.6 2.8 7 111 24.1 19.8 29 45909 9.4 6.8 12.6 10 2.2 1 4 33 7.2 4.9 10.1 46065 45909 3 2024 S92000003 Nervous system conditions Neural Tube Defects Neural Tube Defects 10 0 0 64 74 46065 16.1 12.6 20.2 6 1.3 0.5 2.8 68 14.8 11.5 18.7 45909 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 46065 45909 4 2024 S92000003 Nervous system conditions Neural Tube Defects Anencephaly and similar 1 0 0 29 30 46065 6.5 4.4 9.3 2 0.4 0 1.6 28 6.1 4 8.8 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 5 2024 S92000003 Nervous system conditions Neural Tube Defects Encephalocele and meningocele 4 0 0 13 17 46065 3.7 2.1 5.9 2 0.4 0 1.6 15 3.3 1.8 5.4 45909 0.9 0.2 2.2 1 0.2 0 1.2 3 0.7 0.1 1.9 46065 45909 6 2024 S92000003 Nervous system conditions Neural Tube Defects Spina Bifida 5 0 0 22 27 46065 5.9 3.9 8.5 2 0.4 0 1.6 25 5.4 3.5 8 45909 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46065 45909 7 2024 S92000003 Nervous system conditions Hydrocephalus Hydrocephalus 7 0 0 14 21 46065 4.6 2.8 7 3 0.7 0.1 1.9 18 3.9 2.3 6.2 45909 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.9 46065 45909 8 2024 S92000003 Nervous system conditions Severe microcephaly Severe microcephaly 8 0 0 0 8 46065 1.7 0.7 3.4 3 0.7 0.1 1.9 5 1.1 0.3 2.5 45909 1.7 0.7 3.4 3 0.7 0.1 1.9 5 1.1 0.3 2.5 46065 45909 9 2024 S92000003 Nervous system conditions Arhinencephaly / holoprosencephaly Arhinencephaly / holoprosencephaly 0 0 0 7 7 46065 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 10 2024 S92000003 Nervous system conditions Agenesis of corpus callosum Agenesis of corpus callosum 5 0 0 1 6 46065 1.3 0.5 2.8 3 0.7 0.1 1.9 3 0.7 0.1 1.9 45909 1.1 0.3 2.5 2 0.4 0 1.6 3 0.7 0.1 1.9 46065 45909 11 2024 S92000003 Eye conditions Eye conditions Eye conditions 21 0 0 1 22 46065 4.8 3 7.2 2 0.4 0 1.6 20 4.3 2.7 6.7 45909 4.6 2.8 7 2 0.4 0 1.6 19 4.1 2.5 6.5 46065 45909 12 2024 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos / microphthalmos 3 0 0 0 3 46065 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 45909 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46065 45909 13 2024 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 14 2024 S92000003 Eye conditions Congenital cataract Congenital cataract 6 0 0 0 6 46065 1.3 0.5 2.8 1 0.2 0 1.2 5 1.1 0.3 2.5 45909 1.3 0.5 2.9 1 0.2 0 1.2 5 1.1 0.3 2.5 46065 45909 15 2024 S92000003 Eye conditions Congenital glaucoma Congenital glaucoma 1 0 0 0 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 16 2024 S92000003 Ear, face and neck conditions Ear, face and neck conditions Ear, face and neck conditions 4 0 0 0 4 46065 0.9 0.2 2.2 4 0.9 0.2 2.2 0 0 0 0 45909 0.9 0.2 2.2 4 0.9 0.2 2.2 0 0 0 0 46065 45909 17 2024 S92000003 Ear, face and neck conditions Anotia and atresia/stenosis/stricture of external auditory canal Anotia and atresia/stenosis/stricture of external auditory canal 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 18 2024 S92000003 Congenital heart disease (CHD) Congenital heart disease (CHD) Congenital heart disease (CHD) 256 3 0 62 321 46065 69.7 62.3 77.7 87 18.9 15.1 23.3 234 50.8 44.5 57.7 45909 55.8 49.1 63 61 13.3 10.2 17.1 195 42.5 36.7 48.9 46065 45909 19 2024 S92000003 Congenital heart disease (CHD) Severe CHD Severe CHD 73 2 0 42 117 46065 25.4 21 30.4 33 7.2 4.9 10.1 84 18.2 14.5 22.6 45909 15.9 12.5 20 16 3.5 2 5.7 57 12.4 9.4 16.1 46065 45909 20 2024 S92000003 Congenital heart disease (CHD) Severe CHD Common arterial truncus 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 21 2024 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet right ventricle 1 1 0 6 8 46065 1.7 0.7 3.4 2 0.4 0 1.6 6 1.3 0.5 2.8 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 22 2024 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet left ventricle 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 23 2024 S92000003 Congenital heart disease (CHD) Severe CHD Complete transposition of great arteries (D-TGA) 7 0 0 5 12 46065 2.6 1.3 4.6 0 0 0 0 12 2.6 1.3 4.6 45909 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 46065 45909 24 2024 S92000003 Congenital heart disease (CHD) Severe CHD Single ventricle 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 25 2024 S92000003 Congenital heart disease (CHD) Severe CHD Corrected transposition of great arteries (L-TGA) 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 26 2024 S92000003 Congenital heart disease (CHD) Severe CHD Atrioventricular septal defect (AVSD) 10 1 0 8 19 46065 4.1 2.5 6.4 12 2.6 1.3 4.6 7 1.5 0.6 3.1 45909 2.2 1 4 6 1.3 0.5 2.9 4 0.9 0.2 2.2 46065 45909 27 2024 S92000003 Congenital heart disease (CHD) Severe CHD Tetralogy and pentalogy of Fallot 14 0 0 9 23 46065 5 3.2 7.5 9 2 0.9 3.7 14 3 1.7 5.1 45909 3 1.7 5.1 4 0.9 0.2 2.2 10 2.2 1 4 46065 45909 28 2024 S92000003 Congenital heart disease (CHD) Severe CHD Pulmonary valve atresia 5 0 0 4 9 46065 2 0.9 3.7 3 0.7 0.1 1.9 6 1.3 0.5 2.8 45909 1.1 0.3 2.5 2 0.4 0 1.6 3 0.7 0.1 1.9 46065 45909 29 2024 S92000003 Congenital heart disease (CHD) Severe CHD Triscuspid atresia and stenosis 0 0 0 2 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 30 2024 S92000003 Congenital heart disease (CHD) Severe CHD Ebstein's anomaly 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 31 2024 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic right heart (HRH/HRHS) 1 0 0 1 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 32 2024 S92000003 Congenital heart disease (CHD) Severe CHD Aortic valve atresia/stenosis 3 0 0 0 3 46065 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 45909 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46065 45909 33 2024 S92000003 Congenital heart disease (CHD) Severe CHD Mitral valve atresia/stenosis 1 0 0 0 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 34 2024 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic left heart (HLH/HLHS) 1 1 0 13 15 46065 3.3 1.8 5.4 4 0.9 0.2 2.2 11 2.4 1.2 4.3 45909 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46065 45909 35 2024 S92000003 Congenital heart disease (CHD) Severe CHD Coarctation of aorta 22 0 0 2 24 46065 5.2 3.3 7.8 4 0.9 0.2 2.2 20 4.3 2.7 6.7 45909 4.8 3 7.3 3 0.7 0.1 1.9 19 4.1 2.5 6.5 46065 45909 36 2024 S92000003 Congenital heart disease (CHD) Severe CHD Aortic atresia/interrupted aortic arch 5 0 0 2 7 46065 1.5 0.6 3.1 3 0.7 0.1 1.9 4 0.9 0.2 2.2 45909 1.1 0.3 2.5 1 0.2 0 1.2 4 0.9 0.2 2.2 46065 45909 37 2024 S92000003 Congenital heart disease (CHD) Severe CHD Total anomalous pulmonary venous return 5 0 0 1 6 46065 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 45909 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46065 45909 38 2024 S92000003 Congenital heart disease (CHD) Ventricular septal defect (VSD) Ventricular septal defect (VSD) 116 1 0 25 142 46065 30.8 26 36.3 43 9.3 6.8 12.6 99 21.5 17.5 26.2 45909 25.3 20.9 30.3 33 7.2 4.9 10.1 83 18.1 14.4 22.4 46065 45909 39 2024 S92000003 Congenital heart disease (CHD) Atrial septal defect (ASD) Atrial septal defect (ASD) 54 0 0 0 54 46065 11.7 8.8 15.3 13 2.8 1.5 4.8 41 8.9 6.4 12.1 45909 11.8 8.8 15.3 13 2.8 1.5 4.8 41 8.9 6.4 12.1 46065 45909 40 2024 S92000003 Congenital heart disease (CHD) Pulmonary valve stenosis Pulmonary valve stenosis 27 0 0 2 29 46065 6.3 4.2 9 7 1.5 0.6 3.1 22 4.8 3 7.2 45909 5.9 3.9 8.6 7 1.5 0.6 3.1 20 4.4 2.7 6.7 46065 45909 41 2024 S92000003 Congenital heart disease (CHD) Patent ductus arteriosus (PDA) as only CHD in term infants Patent ductus arteriosus (PDA) as only CHD in term infants 9 0 0 0 9 46065 2 0.9 3.7 3 0.7 0.1 1.9 6 1.3 0.5 2.8 45909 2 0.9 3.7 3 0.7 0.1 1.9 6 1.3 0.5 2.9 46065 45909 42 2024 S92000003 Respiratory conditions Respiratory conditions Respiratory conditions 12 0 0 0 12 46065 2.6 1.3 4.6 6 1.3 0.5 2.8 6 1.3 0.5 2.8 45909 2.6 1.3 4.6 6 1.3 0.5 2.9 6 1.3 0.5 2.9 46065 45909 43 2024 S92000003 Respiratory conditions Choanal stenosis or atresia Choanal stenosis or atresia 4 0 0 0 4 46065 0.9 0.2 2.2 4 0.9 0.2 2.2 0 0 0 0 45909 0.9 0.2 2.2 4 0.9 0.2 2.2 0 0 0 0 46065 45909 44 2024 S92000003 Respiratory conditions Congenital pulmonary airway malformations (CPAM) Congenital pulmonary airway malformations (CPAM) 4 0 0 0 4 46065 0.9 0.2 2.2 1 0.2 0 1.2 3 0.7 0.1 1.9 45909 0.9 0.2 2.2 1 0.2 0 1.2 3 0.7 0.1 1.9 46065 45909 45 2024 S92000003 Oro-facial clefts Oro-facial clefts Oro-facial clefts 59 0 0 11 70 46065 15.2 11.8 19.2 12 2.6 1.3 4.6 58 12.6 9.6 16.3 45909 12.9 9.8 16.6 9 2 0.9 3.7 50 10.9 8.1 14.4 46065 45909 46 2024 S92000003 Oro-facial clefts Cleft lip with or without cleft palate Cleft lip with or without cleft palate 24 0 0 5 29 46065 6.3 4.2 9 2 0.4 0 1.6 27 5.9 3.9 8.5 45909 5.2 3.3 7.8 1 0.2 0 1.2 23 5 3.2 7.5 46065 45909 47 2024 S92000003 Oro-facial clefts Cleft palate without cleft lip Cleft palate without cleft lip 35 0 0 6 41 46065 8.9 6.4 12.1 10 2.2 1 4 31 6.7 4.6 9.6 45909 7.6 5.3 10.6 8 1.7 0.7 3.4 27 5.9 3.9 8.6 46065 45909 48 2024 S92000003 Gastro-intestinal conditions Gastro-intestinal conditions Gastro-intestinal conditions 73 1 0 21 95 46065 20.6 16.7 25.2 15 3.3 1.8 5.4 80 17.4 13.8 21.6 45909 15.9 12.5 20 9 2 0.9 3.7 64 13.9 10.7 17.8 46065 45909 49 2024 S92000003 Gastro-intestinal conditions Oesophageal atresia with or without trachea-oesophageal fistula Oesophageal atresia with or without trachea-oesophageal fistula 12 0 0 0 12 46065 2.6 1.3 4.6 2 0.4 0 1.6 10 2.2 1 4 45909 2.6 1.3 4.6 2 0.4 0 1.6 10 2.2 1 4 46065 45909 50 2024 S92000003 Gastro-intestinal conditions Duodenal atresia or stenosis Duodenal atresia or stenosis 6 0 0 0 6 46065 1.3 0.5 2.8 2 0.4 0 1.6 4 0.9 0.2 2.2 45909 1.3 0.5 2.9 2 0.4 0 1.6 4 0.9 0.2 2.2 46065 45909 51 2024 S92000003 Gastro-intestinal conditions Atresia or stenosis of other parts of small intestine Atresia or stenosis of other parts of small intestine 6 0 0 0 6 46065 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 45909 1.3 0.5 2.9 0 0 0 0 6 1.3 0.5 2.9 46065 45909 52 2024 S92000003 Gastro-intestinal conditions Ano-rectal atresia or stenosis Ano-rectal atresia or stenosis 15 0 0 13 28 46065 6.1 4 8.8 2 0.4 0 1.6 26 5.6 3.7 8.3 45909 3.3 1.8 5.4 0 0 0 0 15 3.3 1.8 5.4 46065 45909 53 2024 S92000003 Gastro-intestinal conditions Hirschsprung's disease Hirschsprung's disease 8 1 0 0 9 46065 2 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 45909 1.7 0.7 3.4 2 0.4 0 1.6 6 1.3 0.5 2.9 46065 45909 54 2024 S92000003 Gastro-intestinal conditions Atresia of bile ducts Atresia of bile ducts 1 0 0 0 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 55 2024 S92000003 Gastro-intestinal conditions Annular pancreas Annular pancreas 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 56 2024 S92000003 Gastro-intestinal conditions Anomalies of intestinal fixation Anomalies of intestinal fixation 9 0 0 2 11 46065 2.4 1.2 4.3 2 0.4 0 1.6 9 2 0.9 3.7 45909 2 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 46065 45909 57 2024 S92000003 Gastro-intestinal conditions Diaphragmatic hernia Diaphragmatic hernia 8 0 0 5 13 46065 2.8 1.5 4.8 2 0.4 0 1.6 11 2.4 1.2 4.3 45909 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 46065 45909 58 2024 S92000003 Abdominal wall defects Abdominal wall defects Abdominal wall defects 13 1 0 18 32 46065 6.9 4.8 9.8 10 2.2 1 4 22 4.8 3 7.2 45909 2.8 1.5 4.8 3 0.7 0.1 1.9 10 2.2 1 4 46065 45909 59 2024 S92000003 Abdominal wall defects Gastroschisis Gastroschisis 8 1 0 0 9 46065 2 0.9 3.7 0 0 0 0 9 2 0.9 3.7 45909 1.7 0.7 3.4 0 0 0 0 8 1.7 0.7 3.4 46065 45909 60 2024 S92000003 Abdominal wall defects Omphalocele Omphalocele 5 0 0 15 20 46065 4.3 2.7 6.7 10 2.2 1 4 10 2.2 1 4 45909 1.1 0.3 2.5 3 0.7 0.1 1.9 2 0.4 0 1.6 46065 45909 61 2024 S92000003 Kidney and urinary tract conditions Kidney and urinary tract conditions Kidney and urinary tract conditions 124 2 1 28 155 46065 33.6 28.6 39.4 15 3.3 1.8 5.4 140 30.4 25.6 35.9 45909 27 22.5 32.2 8 1.7 0.7 3.4 116 25.3 20.9 30.3 46065 45909 62 2024 S92000003 Kidney and urinary tract conditions Unilateral renal agenesis Unilateral renal agenesis 13 1 0 2 16 46065 3.5 2 5.6 1 0.2 0 1.2 15 3.3 1.8 5.4 45909 2.8 1.5 4.8 1 0.2 0 1.2 12 2.6 1.3 4.6 46065 45909 63 2024 S92000003 Kidney and urinary tract conditions Bilateral renal agenesis including Potter sequence Bilateral renal agenesis including Potter sequence 2 0 1 6 9 46065 2 0.9 3.7 0 0 0 0 9 2 0.9 3.7 45909 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46065 45909 64 2024 S92000003 Kidney and urinary tract conditions Multicystic renal dysplasia Multicystic renal dysplasia 15 0 0 6 21 46065 4.6 2.8 7 2 0.4 0 1.6 19 4.1 2.5 6.4 45909 3.3 1.8 5.4 2 0.4 0 1.6 13 2.8 1.5 4.8 46065 45909 65 2024 S92000003 Kidney and urinary tract conditions Congenital hydronephrosis including ureter obstruction Congenital hydronephrosis including ureter obstruction 57 0 0 1 58 46065 12.6 9.6 16.3 4 0.9 0.2 2.2 54 11.7 8.8 15.3 45909 12.4 9.4 16.1 4 0.9 0.2 2.2 53 11.5 8.6 15.1 46065 45909 66 2024 S92000003 Kidney and urinary tract conditions Lobulated, fused and horseshoe kidney and ectopic kidney Lobulated, fused and horseshoe kidney and ectopic kidney 18 0 0 6 24 46065 5.2 3.3 7.8 8 1.7 0.7 3.4 16 3.5 2 5.6 45909 3.9 2.3 6.2 3 0.7 0.1 1.9 15 3.3 1.8 5.4 46065 45909 67 2024 S92000003 Kidney and urinary tract conditions Bladder exstrophy and/or epispadias Bladder exstrophy and/or epispadias 3 0 0 1 4 46065 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45909 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46065 45909 68 2024 S92000003 Kidney and urinary tract conditions Posterior urethral valves Posterior urethral valves 9 0 0 0 9 46065 2 0.9 3.7 0 0 0 0 9 2 0.9 3.7 45909 2 0.9 3.7 0 0 0 0 9 2 0.9 3.7 46065 45909 69 2024 S92000003 Kidney and urinary tract conditions Prune belly syndrome Prune belly syndrome 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 70 2024 S92000003 Genital conditions Genital conditions Genital conditions 75 0 0 6 81 46065 17.6 14 21.9 7 1.5 0.6 3.1 74 16.1 12.6 20.2 45909 16.3 12.9 20.5 6 1.3 0.5 2.9 69 15 11.7 19 46065 45909 71 2024 S92000003 Genital conditions Hypospadias Hypospadias 67 0 0 1 68 46065 14.8 11.5 18.7 6 1.3 0.5 2.8 62 13.5 10.3 17.3 45909 14.6 11.3 18.5 5 1.1 0.3 2.5 62 13.5 10.4 17.3 46065 45909 72 2024 S92000003 Genital conditions Indeterminate sex Indeterminate sex 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 73 2024 S92000003 Limb conditions Limb conditions Limb conditions 106 2 1 21 130 46065 28.2 23.6 33.5 17 3.7 2.1 5.9 113 24.5 20.2 29.5 45909 23.1 18.9 27.9 6 1.3 0.5 2.9 100 21.8 17.7 26.5 46065 45909 74 2024 S92000003 Limb conditions Limb reduction defects (LRD) Limb reduction defects (LRD) 16 1 0 7 24 46065 5.2 3.3 7.8 5 1.1 0.3 2.5 19 4.1 2.5 6.4 45909 3.5 2 5.7 1 0.2 0 1.2 15 3.3 1.8 5.4 46065 45909 75 2024 S92000003 Limb conditions Limb reduction defects (LRD) Transverse LRD 2 0 0 0 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46065 45909 76 2024 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal preaxial LRD 5 1 0 3 9 46065 2 0.9 3.7 3 0.7 0.1 1.9 6 1.3 0.5 2.8 45909 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46065 45909 77 2024 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal postaxial LRD 1 1 0 0 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 78 2024 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal central LRD 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 79 2024 S92000003 Limb conditions Limb reduction defects (LRD) Intercalary LRD 1 0 0 1 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46065 45909 80 2024 S92000003 Limb conditions Club foot/talipes equinovarus Club foot/talipes equinovarus 17 0 0 8 25 46065 5.4 3.5 8 5 1.1 0.3 2.5 20 4.3 2.7 6.7 45909 3.7 2.2 5.9 1 0.2 0 1.2 16 3.5 2 5.7 46065 45909 81 2024 S92000003 Limb conditions Hip dislocation Hip dislocation 4 0 0 0 4 46065 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45909 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46065 45909 82 2024 S92000003 Limb conditions Polydactyly Polydactyly 53 1 0 3 57 46065 12.4 9.4 16 3 0.7 0.1 1.9 54 11.7 8.8 15.3 45909 11.5 8.6 15.1 1 0.2 0 1.2 52 11.3 8.5 14.9 46065 45909 83 2024 S92000003 Limb conditions Syndactyly Syndactyly 13 0 1 2 16 46065 3.5 2 5.6 5 1.1 0.3 2.5 11 2.4 1.2 4.3 45909 2.8 1.5 4.8 2 0.4 0 1.6 11 2.4 1.2 4.3 46065 45909 84 2024 S92000003 Other conditions/syndromes Craniosynostosis Craniosynostosis 24 0 0 0 24 46065 5.2 3.3 7.8 1 0.2 0 1.2 23 5 3.2 7.5 45909 5.2 3.3 7.8 1 0.2 0 1.2 23 5 3.2 7.5 46065 45909 85 2024 S92000003 Other conditions/syndromes Congenital constriction band / Amniotic band sequence resulting in major congenital condition Congenital constriction band / Amniotic band sequence resulting in major congenital condition 2 0 0 0 2 46065 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45909 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46065 45909 86 2024 S92000003 Other conditions/syndromes Situs inversus Situs inversus 3 0 0 0 3 46065 0.7 0.1 1.9 2 0.4 0 1.6 1 0.2 0 1.2 45909 0.7 0.1 1.9 2 0.4 0 1.6 1 0.2 0 1.2 46065 45909 87 2024 S92000003 Other conditions/syndromes Conjoined twins Conjoined twins 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 88 2024 S92000003 Other conditions/syndromes VATER/VACTERL association VATER/VACTERL association 6 0 0 0 6 46065 1.3 0.5 2.8 1 0.2 0 1.2 5 1.1 0.3 2.5 45909 1.3 0.5 2.9 1 0.2 0 1.2 5 1.1 0.3 2.5 46065 45909 89 2024 S92000003 Other conditions/syndromes Pierre-Robin sequence Pierre-Robin sequence 8 0 0 0 8 46065 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 45909 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 46065 45909 90 2024 S92000003 Other conditions/syndromes Caudal regression sequence Caudal regression sequence 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 91 2024 S92000003 Other conditions/syndromes Sirenomelia Sirenomelia 0 0 0 1 1 46065 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 92 2024 S92000003 Other conditions/syndromes Septo-optic dysplasia Septo-optic dysplasia 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 93 2024 S92000003 Other conditions/syndromes Vascular disruption conditions Vascular disruption conditions 19 1 0 0 20 46065 4.3 2.7 6.7 0 0 0 0 20 4.3 2.7 6.7 45909 4.1 2.5 6.5 0 0 0 0 19 4.1 2.5 6.5 46065 45909 94 2024 S92000003 Other conditions/syndromes Laterality conditions Laterality conditions 7 0 0 2 9 46065 2 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 45909 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46065 45909 95 2024 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Teratogenic syndromes resulting in major congenital conditions 2 0 0 0 2 46065 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 45909 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46065 45909 96 2024 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Valproate syndrome 0 0 0 0 0 46065 0 0 0 0 0 0 0 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 97 2024 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Maternal infections resulting in major malformation 2 0 0 0 2 46065 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 45909 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46065 45909 98 2024 S92000003 Genetic conditions Genetic conditions Genetic conditions 136 3 2 172 313 46065 67.9 60.6 75.9 313 67.9 60.6 75.9 0 0 0 0 45909 29.6 24.9 35 136 29.6 24.9 35 0 0 0 0 46065 45909 99 2024 S92000003 Genetic conditions Skeletal dysplasias Skeletal dysplasias 9 0 0 6 15 46065 3.3 1.8 5.4 15 3.3 1.8 5.4 0 0 0 0 45909 2 0.9 3.7 9 2 0.9 3.7 0 0 0 0 46065 45909 100 2024 S92000003 Genetic conditions Skeletal dysplasias Severe skeletal dysplasias 2 0 0 4 6 46065 1.3 0.5 2.8 6 1.3 0.5 2.8 0 0 0 0 45909 0.4 0 1.6 2 0.4 0 1.6 0 0 0 0 46065 45909 101 2024 S92000003 Genetic conditions Down syndrome / trisomy 21 Down syndrome / trisomy 21 53 2 1 79 135 46065 29.3 24.6 34.7 135 29.3 24.6 34.7 0 0 0 0 45909 11.5 8.6 15.1 53 11.5 8.6 15.1 0 0 0 0 46065 45909 102 2024 S92000003 Genetic conditions Patau syndrome / trisomy 13 Patau syndrome / trisomy 13 1 0 0 12 13 46065 2.8 1.5 4.8 13 2.8 1.5 4.8 0 0 0 0 45909 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46065 45909 103 2024 S92000003 Genetic conditions Edwards syndrome / trisomy 18 Edwards syndrome / trisomy 18 6 1 1 33 41 46065 8.9 6.4 12.1 41 8.9 6.4 12.1 0 0 0 0 45909 1.3 0.5 2.9 6 1.3 0.5 2.9 0 0 0 0 46065 45909 104 2024 S92000003 Genetic conditions Turner syndrome / monosomy X Turner syndrome / monosomy X 1 0 0 13 14 46065 3 1.7 5.1 14 3 1.7 5.1 0 0 0 0 45909 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46065 45909 105 2024 S92000003 Genetic conditions Triploidy and polyploidy Triploidy and polyploidy 0 0 0 2 2 46065 0.4 0 1.6 2 0.4 0 1.6 0 0 0 0 45909 0 0 0 0 0 0 0 0 0 0 0 46065 45909 106 2023 S92000003 All conditions All conditions All conditions 820 17 1 329 1167 46111 253.1 238.8 268 312 67.7 60.4 75.6 855 185.4 173.2 198.3 45939 178.5 166.5 191.1 122 26.6 22.1 31.7 698 151.9 140.9 163.6 46111 45939 107 2023 S92000003 Nervous system conditions Nervous system conditions Nervous system conditions 45 6 0 79 130 46111 28.2 23.6 33.5 18 3.9 2.3 6.2 112 24.3 20 29.2 45939 9.8 7.1 13.1 6 1.3 0.5 2.8 39 8.5 6 11.6 46111 45939 108 2023 S92000003 Nervous system conditions Neural Tube Defects Neural Tube Defects 14 3 0 50 67 46111 14.5 11.3 18.5 5 1.1 0.3 2.5 62 13.4 10.3 17.2 45939 3 1.7 5.1 1 0.2 0 1.2 13 2.8 1.5 4.8 46111 45939 109 2023 S92000003 Nervous system conditions Neural Tube Defects Anencephaly and similar 2 2 0 30 34 46111 7.4 5.1 10.3 2 0.4 0 1.6 32 6.9 4.7 9.8 45939 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46111 45939 110 2023 S92000003 Nervous system conditions Neural Tube Defects Encephalocele and meningocele 1 0 0 9 10 46111 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 111 2023 S92000003 Nervous system conditions Neural Tube Defects Spina Bifida 11 1 0 11 23 46111 5 3.2 7.5 2 0.4 0 1.6 21 4.6 2.8 7 45939 2.4 1.2 4.3 1 0.2 0 1.2 10 2.2 1 4 46111 45939 112 2023 S92000003 Nervous system conditions Hydrocephalus Hydrocephalus 7 1 0 10 18 46111 3.9 2.3 6.2 3 0.7 0.1 1.9 15 3.3 1.8 5.4 45939 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.8 46111 45939 113 2023 S92000003 Nervous system conditions Severe microcephaly Severe microcephaly 4 0 0 1 5 46111 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 45939 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46111 45939 114 2023 S92000003 Nervous system conditions Arhinencephaly / holoprosencephaly Arhinencephaly / holoprosencephaly 3 0 0 7 10 46111 2.2 1 4 2 0.4 0 1.6 8 1.7 0.7 3.4 45939 0.7 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 46111 45939 115 2023 S92000003 Nervous system conditions Agenesis of corpus callosum Agenesis of corpus callosum 4 0 0 5 9 46111 2 0.9 3.7 0 0 0 0 9 2 0.9 3.7 45939 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46111 45939 116 2023 S92000003 Eye conditions Eye conditions Eye conditions 29 0 0 0 29 46111 6.3 4.2 9 5 1.1 0.3 2.5 24 5.2 3.3 7.7 45939 6.3 4.2 9.1 5 1.1 0.3 2.5 24 5.2 3.3 7.8 46111 45939 117 2023 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos / microphthalmos 2 0 0 0 2 46111 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 45939 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46111 45939 118 2023 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 119 2023 S92000003 Eye conditions Congenital cataract Congenital cataract 12 0 0 0 12 46111 2.6 1.3 4.5 1 0.2 0 1.2 11 2.4 1.2 4.3 45939 2.6 1.3 4.6 1 0.2 0 1.2 11 2.4 1.2 4.3 46111 45939 120 2023 S92000003 Eye conditions Congenital glaucoma Congenital glaucoma 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 121 2023 S92000003 Ear, face and neck conditions Ear, face and neck conditions Ear, face and neck conditions 2 0 0 1 3 46111 0.7 0.1 1.9 2 0.4 0 1.6 1 0.2 0 1.2 45939 0.4 0 1.6 2 0.4 0 1.6 0 0 0 0 46111 45939 122 2023 S92000003 Ear, face and neck conditions Anotia and atresia/stenosis/stricture of external auditory canal Anotia and atresia/stenosis/stricture of external auditory canal 1 0 0 1 2 46111 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 45939 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46111 45939 123 2023 S92000003 Congenital heart disease (CHD) Congenital heart disease (CHD) Congenital heart disease (CHD) 277 9 0 69 355 46111 77 69.2 85.4 75 16.3 12.8 20.4 280 60.7 53.8 68.3 45939 60.3 53.4 67.8 48 10.4 7.7 13.9 229 49.8 43.6 56.7 46111 45939 124 2023 S92000003 Congenital heart disease (CHD) Severe CHD Severe CHD 105 4 0 41 150 46111 32.5 27.5 38.2 27 5.9 3.9 8.5 123 26.7 22.2 31.8 45939 22.9 18.7 27.7 15 3.3 1.8 5.4 90 19.6 15.8 24.1 46111 45939 125 2023 S92000003 Congenital heart disease (CHD) Severe CHD Common arterial truncus 1 0 0 4 5 46111 1.1 0.3 2.5 2 0.4 0 1.6 3 0.7 0.1 1.9 45939 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46111 45939 126 2023 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet right ventricle 7 0 0 4 11 46111 2.4 1.2 4.3 2 0.4 0 1.6 9 2 0.9 3.7 45939 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.8 46111 45939 127 2023 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet left ventricle 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 128 2023 S92000003 Congenital heart disease (CHD) Severe CHD Complete transposition of great arteries (D-TGA) 12 0 0 9 21 46111 4.6 2.8 7 3 0.7 0.1 1.9 18 3.9 2.3 6.2 45939 2.6 1.3 4.6 0 0 0 0 12 2.6 1.3 4.6 46111 45939 129 2023 S92000003 Congenital heart disease (CHD) Severe CHD Single ventricle 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 130 2023 S92000003 Congenital heart disease (CHD) Severe CHD Corrected transposition of great arteries (L-TGA) 3 0 0 1 4 46111 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45939 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46111 45939 131 2023 S92000003 Congenital heart disease (CHD) Severe CHD Atrioventricular septal defect (AVSD) 10 1 0 6 17 46111 3.7 2.1 5.9 11 2.4 1.2 4.3 6 1.3 0.5 2.8 45939 2.2 1 4 6 1.3 0.5 2.8 4 0.9 0.2 2.2 46111 45939 132 2023 S92000003 Congenital heart disease (CHD) Severe CHD Tetralogy and pentalogy of Fallot 12 0 0 3 15 46111 3.3 1.8 5.4 0 0 0 0 15 3.3 1.8 5.4 45939 2.6 1.3 4.6 0 0 0 0 12 2.6 1.3 4.6 46111 45939 133 2023 S92000003 Congenital heart disease (CHD) Severe CHD Pulmonary valve atresia 6 1 0 2 9 46111 2 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 45939 1.3 0.5 2.8 1 0.2 0 1.2 5 1.1 0.3 2.5 46111 45939 134 2023 S92000003 Congenital heart disease (CHD) Severe CHD Triscuspid atresia and stenosis 1 0 0 3 4 46111 0.9 0.2 2.2 1 0.2 0 1.2 3 0.7 0.1 1.9 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 135 2023 S92000003 Congenital heart disease (CHD) Severe CHD Ebstein's anomaly 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 136 2023 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic right heart (HRH/HRHS) 3 1 0 4 8 46111 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 45939 0.7 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 46111 45939 137 2023 S92000003 Congenital heart disease (CHD) Severe CHD Aortic valve atresia/stenosis 10 1 0 2 13 46111 2.8 1.5 4.8 2 0.4 0 1.6 11 2.4 1.2 4.3 45939 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 46111 45939 138 2023 S92000003 Congenital heart disease (CHD) Severe CHD Mitral valve atresia/stenosis 6 0 0 0 6 46111 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 45939 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46111 45939 139 2023 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic left heart (HLH/HLHS) 7 1 0 13 21 46111 4.6 2.8 7 3 0.7 0.1 1.9 18 3.9 2.3 6.2 45939 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.8 46111 45939 140 2023 S92000003 Congenital heart disease (CHD) Severe CHD Coarctation of aorta 22 0 0 2 24 46111 5.2 3.3 7.7 1 0.2 0 1.2 23 5 3.2 7.5 45939 4.8 3 7.3 1 0.2 0 1.2 21 4.6 2.8 7 46111 45939 141 2023 S92000003 Congenital heart disease (CHD) Severe CHD Aortic atresia/interrupted aortic arch 2 1 0 0 3 46111 0.7 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 45939 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46111 45939 142 2023 S92000003 Congenital heart disease (CHD) Severe CHD Total anomalous pulmonary venous return 4 0 0 0 4 46111 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45939 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46111 45939 143 2023 S92000003 Congenital heart disease (CHD) Ventricular septal defect (VSD) Ventricular septal defect (VSD) 125 6 0 22 153 46111 33.2 28.1 38.9 36 7.8 5.5 10.8 117 25.4 21 30.4 45939 27.2 22.7 32.4 24 5.2 3.3 7.8 101 22 17.9 26.7 46111 45939 144 2023 S92000003 Congenital heart disease (CHD) Atrial septal defect (ASD) Atrial septal defect (ASD) 66 0 0 2 68 46111 14.7 11.5 18.7 21 4.6 2.8 7 47 10.2 7.5 13.6 45939 14.4 11.1 18.3 21 4.6 2.8 7 45 9.8 7.1 13.1 46111 45939 145 2023 S92000003 Congenital heart disease (CHD) Pulmonary valve stenosis Pulmonary valve stenosis 22 0 0 1 23 46111 5 3.2 7.5 4 0.9 0.2 2.2 19 4.1 2.5 6.4 45939 4.8 3 7.3 4 0.9 0.2 2.2 18 3.9 2.3 6.2 46111 45939 146 2023 S92000003 Congenital heart disease (CHD) Patent ductus arteriosus (PDA) as only CHD in term infants Patent ductus arteriosus (PDA) as only CHD in term infants 8 0 0 0 8 46111 1.7 0.7 3.4 2 0.4 0 1.6 6 1.3 0.5 2.8 45939 1.7 0.7 3.4 2 0.4 0 1.6 6 1.3 0.5 2.8 46111 45939 147 2023 S92000003 Respiratory conditions Respiratory conditions Respiratory conditions 16 0 0 3 19 46111 4.1 2.5 6.4 5 1.1 0.3 2.5 14 3 1.7 5.1 45939 3.5 2 5.7 4 0.9 0.2 2.2 12 2.6 1.3 4.6 46111 45939 148 2023 S92000003 Respiratory conditions Choanal stenosis or atresia Choanal stenosis or atresia 4 0 0 0 4 46111 0.9 0.2 2.2 3 0.7 0.1 1.9 1 0.2 0 1.2 45939 0.9 0.2 2.2 3 0.7 0.1 1.9 1 0.2 0 1.2 46111 45939 149 2023 S92000003 Respiratory conditions Congenital pulmonary airway malformations (CPAM) Congenital pulmonary airway malformations (CPAM) 3 0 0 1 4 46111 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45939 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46111 45939 150 2023 S92000003 Oro-facial clefts Oro-facial clefts Oro-facial clefts 75 0 0 12 87 46111 18.9 15.1 23.3 14 3 1.7 5.1 73 15.8 12.4 19.9 45939 16.3 12.8 20.5 8 1.7 0.7 3.4 67 14.6 11.3 18.5 46111 45939 151 2023 S92000003 Oro-facial clefts Cleft lip with or without cleft palate Cleft lip with or without cleft palate 32 0 0 8 40 46111 8.7 6.2 11.8 8 1.7 0.7 3.4 32 6.9 4.7 9.8 45939 7 4.8 9.8 2 0.4 0 1.6 30 6.5 4.4 9.3 46111 45939 152 2023 S92000003 Oro-facial clefts Cleft palate without cleft lip Cleft palate without cleft lip 43 0 0 4 47 46111 10.2 7.5 13.6 6 1.3 0.5 2.8 41 8.9 6.4 12.1 45939 9.4 6.8 12.6 6 1.3 0.5 2.8 37 8.1 5.7 11.1 46111 45939 153 2023 S92000003 Gastro-intestinal conditions Gastro-intestinal conditions Gastro-intestinal conditions 77 3 0 17 97 46111 21 17.1 25.7 17 3.7 2.1 5.9 80 17.3 13.8 21.6 45939 16.8 13.2 20.9 11 2.4 1.2 4.3 66 14.4 11.1 18.3 46111 45939 154 2023 S92000003 Gastro-intestinal conditions Oesophageal atresia with or without trachea-oesophageal fistula Oesophageal atresia with or without trachea-oesophageal fistula 14 0 0 1 15 46111 3.3 1.8 5.4 3 0.7 0.1 1.9 12 2.6 1.3 4.5 45939 3 1.7 5.1 3 0.7 0.1 1.9 11 2.4 1.2 4.3 46111 45939 155 2023 S92000003 Gastro-intestinal conditions Duodenal atresia or stenosis Duodenal atresia or stenosis 7 0 0 0 7 46111 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 45939 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46111 45939 156 2023 S92000003 Gastro-intestinal conditions Atresia or stenosis of other parts of small intestine Atresia or stenosis of other parts of small intestine 7 0 0 0 7 46111 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 45939 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 46111 45939 157 2023 S92000003 Gastro-intestinal conditions Ano-rectal atresia or stenosis Ano-rectal atresia or stenosis 9 0 0 3 12 46111 2.6 1.3 4.5 1 0.2 0 1.2 11 2.4 1.2 4.3 45939 2 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 46111 45939 158 2023 S92000003 Gastro-intestinal conditions Hirschsprung's disease Hirschsprung's disease 6 0 0 0 6 46111 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 45939 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46111 45939 159 2023 S92000003 Gastro-intestinal conditions Atresia of bile ducts Atresia of bile ducts 4 0 0 0 4 46111 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45939 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46111 45939 160 2023 S92000003 Gastro-intestinal conditions Annular pancreas Annular pancreas 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 161 2023 S92000003 Gastro-intestinal conditions Anomalies of intestinal fixation Anomalies of intestinal fixation 7 0 0 2 9 46111 2 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 45939 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.8 46111 45939 162 2023 S92000003 Gastro-intestinal conditions Diaphragmatic hernia Diaphragmatic hernia 9 1 0 8 18 46111 3.9 2.3 6.2 5 1.1 0.3 2.5 13 2.8 1.5 4.8 45939 2 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 46111 45939 163 2023 S92000003 Abdominal wall defects Abdominal wall defects Abdominal wall defects 20 1 0 18 39 46111 8.5 6 11.6 12 2.6 1.3 4.5 27 5.9 3.9 8.5 45939 4.4 2.7 6.7 2 0.4 0 1.6 18 3.9 2.3 6.2 46111 45939 164 2023 S92000003 Abdominal wall defects Gastroschisis Gastroschisis 13 0 0 4 17 46111 3.7 2.1 5.9 1 0.2 0 1.2 16 3.5 2 5.6 45939 2.8 1.5 4.8 0 0 0 0 13 2.8 1.5 4.8 46111 45939 165 2023 S92000003 Abdominal wall defects Omphalocele Omphalocele 7 1 0 9 17 46111 3.7 2.1 5.9 9 2 0.9 3.7 8 1.7 0.7 3.4 45939 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46111 45939 166 2023 S92000003 Kidney and urinary tract conditions Kidney and urinary tract conditions Kidney and urinary tract conditions 106 1 0 34 141 46111 30.6 25.7 36.1 9 2 0.9 3.7 132 28.6 24 33.9 45939 23.1 18.9 27.9 4 0.9 0.2 2.2 102 22.2 18.1 27 46111 45939 167 2023 S92000003 Kidney and urinary tract conditions Unilateral renal agenesis Unilateral renal agenesis 10 0 0 11 21 46111 4.6 2.8 7 3 0.7 0.1 1.9 18 3.9 2.3 6.2 45939 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 46111 45939 168 2023 S92000003 Kidney and urinary tract conditions Bilateral renal agenesis including Potter sequence Bilateral renal agenesis including Potter sequence 3 0 0 4 7 46111 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 45939 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46111 45939 169 2023 S92000003 Kidney and urinary tract conditions Multicystic renal dysplasia Multicystic renal dysplasia 16 0 0 8 24 46111 5.2 3.3 7.7 3 0.7 0.1 1.9 21 4.6 2.8 7 45939 3.5 2 5.7 1 0.2 0 1.2 15 3.3 1.8 5.4 46111 45939 170 2023 S92000003 Kidney and urinary tract conditions Congenital hydronephrosis including ureter obstruction Congenital hydronephrosis including ureter obstruction 45 0 0 0 45 46111 9.8 7.1 13.1 0 0 0 0 45 9.8 7.1 13.1 45939 9.8 7.1 13.1 0 0 0 0 45 9.8 7.1 13.1 46111 45939 171 2023 S92000003 Kidney and urinary tract conditions Lobulated, fused and horseshoe kidney and ectopic kidney Lobulated, fused and horseshoe kidney and ectopic kidney 14 0 0 1 15 46111 3.3 1.8 5.4 0 0 0 0 15 3.3 1.8 5.4 45939 3 1.7 5.1 0 0 0 0 14 3 1.7 5.1 46111 45939 172 2023 S92000003 Kidney and urinary tract conditions Bladder exstrophy and/or epispadias Bladder exstrophy and/or epispadias 3 0 0 2 5 46111 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 45939 0.7 0.1 1.9 0 0 0 0 3 0.7 0.1 1.9 46111 45939 173 2023 S92000003 Kidney and urinary tract conditions Posterior urethral valves Posterior urethral valves 12 0 0 4 16 46111 3.5 2 5.6 0 0 0 0 16 3.5 2 5.6 45939 2.6 1.3 4.6 0 0 0 0 12 2.6 1.3 4.6 46111 45939 174 2023 S92000003 Kidney and urinary tract conditions Prune belly syndrome Prune belly syndrome 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 175 2023 S92000003 Genital conditions Genital conditions Genital conditions 81 0 0 5 86 46111 18.7 14.9 23 6 1.3 0.5 2.8 80 17.3 13.8 21.6 45939 17.6 14 21.9 5 1.1 0.3 2.5 76 16.5 13 20.7 46111 45939 176 2023 S92000003 Genital conditions Hypospadias Hypospadias 71 0 0 2 73 46111 15.8 12.4 19.9 5 1.1 0.3 2.5 68 14.7 11.5 18.7 45939 15.5 12.1 19.5 4 0.9 0.2 2.2 67 14.6 11.3 18.5 46111 45939 177 2023 S92000003 Genital conditions Indeterminate sex Indeterminate sex 0 0 0 1 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 178 2023 S92000003 Limb conditions Limb conditions Limb conditions 110 3 0 26 139 46111 30.1 25.3 35.6 26 5.6 3.7 8.3 113 24.5 20.2 29.5 45939 23.9 19.7 28.9 13 2.8 1.5 4.8 97 21.1 17.1 25.8 46111 45939 179 2023 S92000003 Limb conditions Limb reduction defects (LRD) Limb reduction defects (LRD) 9 0 0 7 16 46111 3.5 2 5.6 4 0.9 0.2 2.2 12 2.6 1.3 4.5 45939 2 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 46111 45939 180 2023 S92000003 Limb conditions Limb reduction defects (LRD) Transverse LRD 2 0 0 2 4 46111 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 45939 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46111 45939 181 2023 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal preaxial LRD 3 0 0 1 4 46111 0.9 0.2 2.2 1 0.2 0 1.2 3 0.7 0.1 1.9 45939 0.7 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 46111 45939 182 2023 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal postaxial LRD 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 183 2023 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal central LRD 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 184 2023 S92000003 Limb conditions Limb reduction defects (LRD) Intercalary LRD 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 185 2023 S92000003 Limb conditions Club foot/talipes equinovarus Club foot/talipes equinovarus 18 2 0 3 23 46111 5 3.2 7.5 4 0.9 0.2 2.2 19 4.1 2.5 6.4 45939 3.9 2.3 6.2 1 0.2 0 1.2 17 3.7 2.2 5.9 46111 45939 186 2023 S92000003 Limb conditions Hip dislocation Hip dislocation 10 0 0 0 10 46111 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 45939 2.2 1 4 1 0.2 0 1.2 9 2 0.9 3.7 46111 45939 187 2023 S92000003 Limb conditions Polydactyly Polydactyly 58 1 0 8 67 46111 14.5 11.3 18.5 8 1.7 0.7 3.4 59 12.8 9.7 16.5 45939 12.6 9.6 16.3 3 0.7 0.1 1.9 55 12 9 15.6 46111 45939 188 2023 S92000003 Limb conditions Syndactyly Syndactyly 7 0 0 2 9 46111 2 0.9 3.7 4 0.9 0.2 2.2 5 1.1 0.3 2.5 45939 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46111 45939 189 2023 S92000003 Other conditions/syndromes Craniosynostosis Craniosynostosis 19 0 0 0 19 46111 4.1 2.5 6.4 6 1.3 0.5 2.8 13 2.8 1.5 4.8 45939 4.1 2.5 6.5 6 1.3 0.5 2.8 13 2.8 1.5 4.8 46111 45939 190 2023 S92000003 Other conditions/syndromes Congenital constriction band / Amniotic band sequence resulting in major congenital condition Congenital constriction band / Amniotic band sequence resulting in major congenital condition 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 191 2023 S92000003 Other conditions/syndromes Situs inversus Situs inversus 5 0 0 1 6 46111 1.3 0.5 2.8 2 0.4 0 1.6 4 0.9 0.2 2.2 45939 1.1 0.3 2.5 2 0.4 0 1.6 3 0.7 0.1 1.9 46111 45939 192 2023 S92000003 Other conditions/syndromes Conjoined twins Conjoined twins 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 193 2023 S92000003 Other conditions/syndromes VATER/VACTERL association VATER/VACTERL association 7 0 0 3 10 46111 2.2 1 4 0 0 0 0 10 2.2 1 4 45939 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 46111 45939 194 2023 S92000003 Other conditions/syndromes Pierre-Robin sequence Pierre-Robin sequence 12 0 0 0 12 46111 2.6 1.3 4.5 3 0.7 0.1 1.9 9 2 0.9 3.7 45939 2.6 1.3 4.6 3 0.7 0.1 1.9 9 2 0.9 3.7 46111 45939 195 2023 S92000003 Other conditions/syndromes Caudal regression sequence Caudal regression sequence 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 196 2023 S92000003 Other conditions/syndromes Sirenomelia Sirenomelia 0 0 0 2 2 46111 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 197 2023 S92000003 Other conditions/syndromes Septo-optic dysplasia Septo-optic dysplasia 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 198 2023 S92000003 Other conditions/syndromes Vascular disruption conditions Vascular disruption conditions 22 0 0 5 27 46111 5.9 3.9 8.5 1 0.2 0 1.2 26 5.6 3.7 8.3 45939 4.8 3 7.3 0 0 0 0 22 4.8 3 7.3 46111 45939 199 2023 S92000003 Other conditions/syndromes Laterality conditions Laterality conditions 7 0 0 3 10 46111 2.2 1 4 2 0.4 0 1.6 8 1.7 0.7 3.4 45939 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46111 45939 200 2023 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Teratogenic syndromes resulting in major congenital conditions 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 201 2023 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Valproate syndrome 0 0 0 0 0 46111 0 0 0 0 0 0 0 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 202 2023 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Maternal infections resulting in major malformation 1 0 0 0 1 46111 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 45939 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46111 45939 203 2023 S92000003 Genetic conditions Genetic conditions Genetic conditions 122 9 1 180 312 46111 67.7 60.4 75.6 312 67.7 60.4 75.6 0 0 0 0 45939 26.6 22.1 31.7 122 26.6 22.1 31.7 0 0 0 0 46111 45939 204 2023 S92000003 Genetic conditions Skeletal dysplasias Skeletal dysplasias 5 0 0 6 11 46111 2.4 1.2 4.3 11 2.4 1.2 4.3 0 0 0 0 45939 1.1 0.3 2.5 5 1.1 0.3 2.5 0 0 0 0 46111 45939 205 2023 S92000003 Genetic conditions Skeletal dysplasias Severe skeletal dysplasias 0 0 0 6 6 46111 1.3 0.5 2.8 6 1.3 0.5 2.8 0 0 0 0 45939 0 0 0 0 0 0 0 0 0 0 0 46111 45939 206 2023 S92000003 Genetic conditions Down syndrome / trisomy 21 Down syndrome / trisomy 21 43 2 0 75 120 46111 26 21.6 31.1 120 26 21.6 31.1 0 0 0 0 45939 9.4 6.8 12.6 43 9.4 6.8 12.6 0 0 0 0 46111 45939 207 2023 S92000003 Genetic conditions Patau syndrome / trisomy 13 Patau syndrome / trisomy 13 1 0 0 16 17 46111 3.7 2.1 5.9 17 3.7 2.1 5.9 0 0 0 0 45939 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46111 45939 208 2023 S92000003 Genetic conditions Edwards syndrome / trisomy 18 Edwards syndrome / trisomy 18 2 4 0 38 44 46111 9.5 6.9 12.8 44 9.5 6.9 12.8 0 0 0 0 45939 0.4 0 1.6 2 0.4 0 1.6 0 0 0 0 46111 45939 209 2023 S92000003 Genetic conditions Turner syndrome / monosomy X Turner syndrome / monosomy X 2 0 0 13 15 46111 3.3 1.8 5.4 15 3.3 1.8 5.4 0 0 0 0 45939 0.4 0 1.6 2 0.4 0 1.6 0 0 0 0 46111 45939 210 2023 S92000003 Genetic conditions Triploidy and polyploidy Triploidy and polyploidy 1 1 0 7 9 46111 2 0.9 3.7 9 2 0.9 3.7 0 0 0 0 45939 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46111 45939 211 2022 S92000003 All conditions All conditions All conditions 870 21 6 324 1221 46779 261 246.6 276.1 330 70.5 63.1 78.6 891 190.5 178.2 203.4 46603 186.7 174.5 199.5 139 29.8 25.1 35.2 731 156.9 145.7 168.6 46779 46603 212 2022 S92000003 Nervous system conditions Nervous system conditions Nervous system conditions 50 4 0 85 139 46779 29.7 25 35.1 24 5.1 3.3 7.6 115 24.6 20.3 29.5 46603 10.7 8 14.1 7 1.5 0.6 3.1 43 9.2 6.7 12.4 46779 46603 213 2022 S92000003 Nervous system conditions Neural Tube Defects Neural Tube Defects 14 2 0 53 69 46779 14.8 11.5 18.7 4 0.9 0.2 2.2 65 13.9 10.7 17.7 46603 3 1.6 5 0 0 0 0 14 3 1.6 5 46779 46603 214 2022 S92000003 Nervous system conditions Neural Tube Defects Anencephaly and similar 0 1 0 18 19 46779 4.1 2.4 6.3 0 0 0 0 19 4.1 2.4 6.3 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 215 2022 S92000003 Nervous system conditions Neural Tube Defects Encephalocele and meningocele 2 0 0 10 12 46779 2.6 1.3 4.5 1 0.2 0 1.2 11 2.4 1.2 4.2 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 216 2022 S92000003 Nervous system conditions Neural Tube Defects Spina Bifida 12 1 0 25 38 46779 8.1 5.7 11.1 3 0.6 0.1 1.9 35 7.5 5.2 10.4 46603 2.6 1.3 4.5 0 0 0 0 12 2.6 1.3 4.5 46779 46603 217 2022 S92000003 Nervous system conditions Hydrocephalus Hydrocephalus 13 1 0 16 30 46779 6.4 4.3 9.2 2 0.4 0 1.6 28 6 4 8.7 46603 2.8 1.5 4.8 1 0.2 0 1.2 12 2.6 1.3 4.5 46779 46603 218 2022 S92000003 Nervous system conditions Severe microcephaly Severe microcephaly 4 0 0 1 5 46779 1.1 0.3 2.5 2 0.4 0 1.6 3 0.6 0.1 1.9 46603 0.9 0.2 2.2 1 0.2 0 1.2 3 0.6 0.1 1.9 46779 46603 219 2022 S92000003 Nervous system conditions Arhinencephaly / holoprosencephaly Arhinencephaly / holoprosencephaly 1 0 0 11 12 46779 2.6 1.3 4.5 9 1.9 0.9 3.7 3 0.6 0.1 1.9 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 220 2022 S92000003 Nervous system conditions Agenesis of corpus callosum Agenesis of corpus callosum 4 1 0 2 7 46779 1.5 0.6 3.1 1 0.2 0 1.2 6 1.3 0.5 2.8 46603 0.9 0.2 2.2 1 0.2 0 1.2 3 0.6 0.1 1.9 46779 46603 221 2022 S92000003 Eye conditions Eye conditions Eye conditions 20 0 0 1 21 46779 4.5 2.8 6.9 7 1.5 0.6 3.1 14 3 1.6 5 46603 4.3 2.6 6.6 7 1.5 0.6 3.1 13 2.8 1.5 4.8 46779 46603 222 2022 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos / microphthalmos 2 0 0 1 3 46779 0.6 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 46603 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46779 46603 223 2022 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos 0 0 0 1 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 224 2022 S92000003 Eye conditions Congenital cataract Congenital cataract 10 0 0 0 10 46779 2.1 1 3.9 2 0.4 0 1.6 8 1.7 0.7 3.4 46603 2.1 1 4 2 0.4 0 1.6 8 1.7 0.7 3.4 46779 46603 225 2022 S92000003 Eye conditions Congenital glaucoma Congenital glaucoma 1 0 0 0 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 226 2022 S92000003 Ear, face and neck conditions Ear, face and neck conditions Ear, face and neck conditions 2 0 0 2 4 46779 0.9 0.2 2.2 1 0.2 0 1.2 3 0.6 0.1 1.9 46603 0.4 0 1.6 1 0.2 0 1.2 1 0.2 0 1.2 46779 46603 227 2022 S92000003 Ear, face and neck conditions Anotia and atresia/stenosis/stricture of external auditory canal Anotia and atresia/stenosis/stricture of external auditory canal 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 228 2022 S92000003 Congenital heart disease (CHD) Congenital heart disease (CHD) Congenital heart disease (CHD) 309 7 2 57 375 46779 80.2 72.3 88.7 72 15.4 12 19.4 303 64.8 57.7 72.5 46603 66.3 59.1 74.1 57 12.2 9.3 15.8 252 54.1 47.6 61.2 46779 46603 229 2022 S92000003 Congenital heart disease (CHD) Severe CHD Severe CHD 112 4 1 30 147 46779 31.4 26.6 36.9 32 6.8 4.7 9.7 115 24.6 20.3 29.5 46603 24 19.8 28.9 23 4.9 3.1 7.4 89 19.1 15.3 23.5 46779 46603 230 2022 S92000003 Congenital heart disease (CHD) Severe CHD Common arterial truncus 2 0 0 1 3 46779 0.6 0.1 1.9 0 0 0 0 3 0.6 0.1 1.9 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 231 2022 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet right ventricle 9 1 0 6 16 46779 3.4 2 5.6 1 0.2 0 1.2 15 3.2 1.8 5.3 46603 1.9 0.9 3.7 0 0 0 0 9 1.9 0.9 3.7 46779 46603 232 2022 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet left ventricle 1 0 0 0 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 233 2022 S92000003 Congenital heart disease (CHD) Severe CHD Complete transposition of great arteries (D-TGA) 22 0 0 6 28 46779 6 4 8.7 0 0 0 0 28 6 4 8.7 46603 4.7 3 7.1 0 0 0 0 22 4.7 3 7.1 46779 46603 234 2022 S92000003 Congenital heart disease (CHD) Severe CHD Single ventricle 1 0 0 0 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 235 2022 S92000003 Congenital heart disease (CHD) Severe CHD Corrected transposition of great arteries (L-TGA) 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 236 2022 S92000003 Congenital heart disease (CHD) Severe CHD Atrioventricular septal defect (AVSD) 16 1 1 8 26 46779 5.6 3.6 8.1 16 3.4 2 5.6 10 2.1 1 3.9 46603 3.4 2 5.6 10 2.1 1 4 6 1.3 0.5 2.8 46779 46603 237 2022 S92000003 Congenital heart disease (CHD) Severe CHD Tetralogy and pentalogy of Fallot 21 0 0 3 24 46779 5.1 3.3 7.6 4 0.9 0.2 2.2 20 4.3 2.6 6.6 46603 4.5 2.8 6.9 3 0.6 0.1 1.9 18 3.9 2.3 6.1 46779 46603 238 2022 S92000003 Congenital heart disease (CHD) Severe CHD Pulmonary valve atresia 3 1 0 2 6 46779 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46603 0.6 0.1 1.9 0 0 0 0 3 0.6 0.1 1.9 46779 46603 239 2022 S92000003 Congenital heart disease (CHD) Severe CHD Triscuspid atresia and stenosis 5 0 0 2 7 46779 1.5 0.6 3.1 0 0 0 0 7 1.5 0.6 3.1 46603 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46779 46603 240 2022 S92000003 Congenital heart disease (CHD) Severe CHD Ebstein's anomaly 3 0 0 1 4 46779 0.9 0.2 2.2 1 0.2 0 1.2 3 0.6 0.1 1.9 46603 0.6 0.1 1.9 1 0.2 0 1.2 2 0.4 0 1.6 46779 46603 241 2022 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic right heart (HRH/HRHS) 2 0 0 4 6 46779 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 242 2022 S92000003 Congenital heart disease (CHD) Severe CHD Aortic valve atresia/stenosis 9 0 0 0 9 46779 1.9 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 46603 1.9 0.9 3.7 1 0.2 0 1.2 8 1.7 0.7 3.4 46779 46603 243 2022 S92000003 Congenital heart disease (CHD) Severe CHD Mitral valve atresia/stenosis 2 0 0 0 2 46779 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 244 2022 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic left heart (HLH/HLHS) 2 0 0 6 8 46779 1.7 0.7 3.4 0 0 0 0 8 1.7 0.7 3.4 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 245 2022 S92000003 Congenital heart disease (CHD) Severe CHD Coarctation of aorta 27 0 0 0 27 46779 5.8 3.8 8.4 5 1.1 0.3 2.5 22 4.7 2.9 7.1 46603 5.8 3.8 8.4 5 1.1 0.3 2.5 22 4.7 3 7.1 46779 46603 246 2022 S92000003 Congenital heart disease (CHD) Severe CHD Aortic atresia/interrupted aortic arch 5 0 0 1 6 46779 1.3 0.5 2.8 2 0.4 0 1.6 4 0.9 0.2 2.2 46603 1.1 0.3 2.5 1 0.2 0 1.2 4 0.9 0.2 2.2 46779 46603 247 2022 S92000003 Congenital heart disease (CHD) Severe CHD Total anomalous pulmonary venous return 8 0 0 2 10 46779 2.1 1 3.9 1 0.2 0 1.2 9 1.9 0.9 3.7 46603 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 46779 46603 248 2022 S92000003 Congenital heart disease (CHD) Ventricular septal defect (VSD) Ventricular septal defect (VSD) 155 3 1 19 178 46779 38.1 32.7 44.1 27 5.8 3.8 8.4 151 32.3 27.3 37.9 46603 33.3 28.2 38.9 22 4.7 3 7.1 133 28.5 23.9 33.8 46779 46603 249 2022 S92000003 Congenital heart disease (CHD) Atrial septal defect (ASD) Atrial septal defect (ASD) 50 0 0 2 52 46779 11.1 8.3 14.6 12 2.6 1.3 4.5 40 8.6 6.1 11.6 46603 10.7 8 14.1 12 2.6 1.3 4.5 38 8.2 5.8 11.2 46779 46603 250 2022 S92000003 Congenital heart disease (CHD) Pulmonary valve stenosis Pulmonary valve stenosis 29 0 0 0 29 46779 6.2 4.2 8.9 4 0.9 0.2 2.2 25 5.3 3.5 7.9 46603 6.2 4.2 8.9 4 0.9 0.2 2.2 25 5.4 3.5 7.9 46779 46603 251 2022 S92000003 Congenital heart disease (CHD) Patent ductus arteriosus (PDA) as only CHD in term infants Patent ductus arteriosus (PDA) as only CHD in term infants 11 0 0 0 11 46779 2.4 1.2 4.2 3 0.6 0.1 1.9 8 1.7 0.7 3.4 46603 2.4 1.2 4.2 3 0.6 0.1 1.9 8 1.7 0.7 3.4 46779 46603 252 2022 S92000003 Respiratory conditions Respiratory conditions Respiratory conditions 15 0 0 5 20 46779 4.3 2.6 6.6 6 1.3 0.5 2.8 14 3 1.6 5 46603 3.2 1.8 5.3 6 1.3 0.5 2.8 9 1.9 0.9 3.7 46779 46603 253 2022 S92000003 Respiratory conditions Choanal stenosis or atresia Choanal stenosis or atresia 7 0 0 0 7 46779 1.5 0.6 3.1 5 1.1 0.3 2.5 2 0.4 0 1.6 46603 1.5 0.6 3.1 5 1.1 0.3 2.5 2 0.4 0 1.6 46779 46603 254 2022 S92000003 Respiratory conditions Congenital pulmonary airway malformations (CPAM) Congenital pulmonary airway malformations (CPAM) 1 0 0 1 2 46779 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 255 2022 S92000003 Oro-facial clefts Oro-facial clefts Oro-facial clefts 63 0 0 12 75 46779 16 12.6 20.1 8 1.7 0.7 3.4 67 14.3 11.1 18.2 46603 13.5 10.4 17.3 7 1.5 0.6 3.1 56 12 9.1 15.6 46779 46603 256 2022 S92000003 Oro-facial clefts Cleft lip with or without cleft palate Cleft lip with or without cleft palate 33 0 0 10 43 46779 9.2 6.7 12.4 3 0.6 0.1 1.9 40 8.6 6.1 11.6 46603 7.1 4.9 9.9 2 0.4 0 1.6 31 6.7 4.5 9.4 46779 46603 257 2022 S92000003 Oro-facial clefts Cleft palate without cleft lip Cleft palate without cleft lip 30 0 0 2 32 46779 6.8 4.7 9.7 5 1.1 0.3 2.5 27 5.8 3.8 8.4 46603 6.4 4.3 9.2 5 1.1 0.3 2.5 25 5.4 3.5 7.9 46779 46603 258 2022 S92000003 Gastro-intestinal conditions Gastro-intestinal conditions Gastro-intestinal conditions 99 2 0 17 118 46779 25.2 20.9 30.2 16 3.4 2 5.6 102 21.8 17.8 26.5 46603 21.2 17.3 25.9 12 2.6 1.3 4.5 87 18.7 15 23 46779 46603 259 2022 S92000003 Gastro-intestinal conditions Oesophageal atresia with or without trachea-oesophageal fistula Oesophageal atresia with or without trachea-oesophageal fistula 18 0 0 2 20 46779 4.3 2.6 6.6 1 0.2 0 1.2 19 4.1 2.4 6.3 46603 3.9 2.3 6.1 1 0.2 0 1.2 17 3.6 2.1 5.8 46779 46603 260 2022 S92000003 Gastro-intestinal conditions Duodenal atresia or stenosis Duodenal atresia or stenosis 6 0 0 1 7 46779 1.5 0.6 3.1 4 0.9 0.2 2.2 3 0.6 0.1 1.9 46603 1.3 0.5 2.8 3 0.6 0.1 1.9 3 0.6 0.1 1.9 46779 46603 261 2022 S92000003 Gastro-intestinal conditions Atresia or stenosis of other parts of small intestine Atresia or stenosis of other parts of small intestine 6 0 0 0 6 46779 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46603 1.3 0.5 2.8 0 0 0 0 6 1.3 0.5 2.8 46779 46603 262 2022 S92000003 Gastro-intestinal conditions Ano-rectal atresia or stenosis Ano-rectal atresia or stenosis 19 0 0 3 22 46779 4.7 2.9 7.1 2 0.4 0 1.6 20 4.3 2.6 6.6 46603 4.1 2.5 6.4 2 0.4 0 1.6 17 3.6 2.1 5.8 46779 46603 263 2022 S92000003 Gastro-intestinal conditions Hirschsprung's disease Hirschsprung's disease 10 0 0 0 10 46779 2.1 1 3.9 1 0.2 0 1.2 9 1.9 0.9 3.7 46603 2.1 1 4 1 0.2 0 1.2 9 1.9 0.9 3.7 46779 46603 264 2022 S92000003 Gastro-intestinal conditions Atresia of bile ducts Atresia of bile ducts 2 0 0 0 2 46779 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 265 2022 S92000003 Gastro-intestinal conditions Annular pancreas Annular pancreas 1 0 0 0 1 46779 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46603 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46779 46603 266 2022 S92000003 Gastro-intestinal conditions Anomalies of intestinal fixation Anomalies of intestinal fixation 12 0 0 6 18 46779 3.8 2.3 6.1 5 1.1 0.3 2.5 13 2.8 1.5 4.8 46603 2.6 1.3 4.5 3 0.6 0.1 1.9 9 1.9 0.9 3.7 46779 46603 267 2022 S92000003 Gastro-intestinal conditions Diaphragmatic hernia Diaphragmatic hernia 15 0 0 3 18 46779 3.8 2.3 6.1 2 0.4 0 1.6 16 3.4 2 5.6 46603 3.2 1.8 5.3 1 0.2 0 1.2 14 3 1.6 5 46779 46603 268 2022 S92000003 Abdominal wall defects Abdominal wall defects Abdominal wall defects 20 0 0 22 42 46779 9 6.5 12.1 8 1.7 0.7 3.4 34 7.3 5 10.2 46603 4.3 2.6 6.6 1 0.2 0 1.2 19 4.1 2.5 6.4 46779 46603 269 2022 S92000003 Abdominal wall defects Gastroschisis Gastroschisis 13 0 0 1 14 46779 3 1.6 5 0 0 0 0 14 3 1.6 5 46603 2.8 1.5 4.8 0 0 0 0 13 2.8 1.5 4.8 46779 46603 270 2022 S92000003 Abdominal wall defects Omphalocele Omphalocele 8 0 0 14 22 46779 4.7 2.9 7.1 8 1.7 0.7 3.4 14 3 1.6 5 46603 1.7 0.7 3.4 1 0.2 0 1.2 7 1.5 0.6 3.1 46779 46603 271 2022 S92000003 Kidney and urinary tract conditions Kidney and urinary tract conditions Kidney and urinary tract conditions 108 1 0 31 140 46779 29.9 25.2 35.3 14 3 1.6 5 126 26.9 22.4 32.1 46603 23.2 19 28 10 2.1 1 4 98 21 17.1 25.6 46779 46603 272 2022 S92000003 Kidney and urinary tract conditions Unilateral renal agenesis Unilateral renal agenesis 11 0 0 3 14 46779 3 1.6 5 1 0.2 0 1.2 13 2.8 1.5 4.8 46603 2.4 1.2 4.2 1 0.2 0 1.2 10 2.1 1 4 46779 46603 273 2022 S92000003 Kidney and urinary tract conditions Bilateral renal agenesis including Potter sequence Bilateral renal agenesis including Potter sequence 1 1 0 5 7 46779 1.5 0.6 3.1 2 0.4 0 1.6 5 1.1 0.3 2.5 46603 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46779 46603 274 2022 S92000003 Kidney and urinary tract conditions Multicystic renal dysplasia Multicystic renal dysplasia 17 0 0 6 23 46779 4.9 3.1 7.4 0 0 0 0 23 4.9 3.1 7.4 46603 3.6 2.1 5.8 0 0 0 0 17 3.6 2.1 5.8 46779 46603 275 2022 S92000003 Kidney and urinary tract conditions Congenital hydronephrosis including ureter obstruction Congenital hydronephrosis including ureter obstruction 44 0 0 1 45 46779 9.6 7 12.9 6 1.3 0.5 2.8 39 8.3 5.9 11.4 46603 9.4 6.9 12.7 5 1.1 0.3 2.5 39 8.4 6 11.4 46779 46603 276 2022 S92000003 Kidney and urinary tract conditions Lobulated, fused and horseshoe kidney and ectopic kidney Lobulated, fused and horseshoe kidney and ectopic kidney 11 0 0 2 13 46779 2.8 1.5 4.8 1 0.2 0 1.2 12 2.6 1.3 4.5 46603 2.4 1.2 4.2 1 0.2 0 1.2 10 2.1 1 4 46779 46603 277 2022 S92000003 Kidney and urinary tract conditions Bladder exstrophy and/or epispadias Bladder exstrophy and/or epispadias 4 0 0 0 4 46779 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46603 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46779 46603 278 2022 S92000003 Kidney and urinary tract conditions Posterior urethral valves Posterior urethral valves 12 0 0 6 18 46779 3.8 2.3 6.1 1 0.2 0 1.2 17 3.6 2.1 5.8 46603 2.6 1.3 4.5 1 0.2 0 1.2 11 2.4 1.2 4.2 46779 46603 279 2022 S92000003 Kidney and urinary tract conditions Prune belly syndrome Prune belly syndrome 0 0 0 1 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 280 2022 S92000003 Genital conditions Genital conditions Genital conditions 95 0 0 0 95 46779 20.3 16.4 24.8 4 0.9 0.2 2.2 91 19.5 15.7 23.9 46603 20.4 16.5 24.9 4 0.9 0.2 2.2 91 19.5 15.7 24 46779 46603 281 2022 S92000003 Genital conditions Hypospadias Hypospadias 84 0 0 0 84 46779 18 14.3 22.2 3 0.6 0.1 1.9 81 17.3 13.8 21.5 46603 18 14.4 22.3 3 0.6 0.1 1.9 81 17.4 13.8 21.6 46779 46603 282 2022 S92000003 Genital conditions Indeterminate sex Indeterminate sex 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 283 2022 S92000003 Limb conditions Limb conditions Limb conditions 131 2 0 35 168 46779 35.9 30.7 41.8 32 6.8 4.7 9.7 136 29.1 24.4 34.4 46603 28.1 23.5 33.4 15 3.2 1.8 5.3 116 24.9 20.6 29.9 46779 46603 284 2022 S92000003 Limb conditions Limb reduction defects (LRD) Limb reduction defects (LRD) 14 0 0 14 28 46779 6 4 8.7 6 1.3 0.5 2.8 22 4.7 2.9 7.1 46603 3 1.6 5 1 0.2 0 1.2 13 2.8 1.5 4.8 46779 46603 285 2022 S92000003 Limb conditions Limb reduction defects (LRD) Transverse LRD 1 0 0 4 5 46779 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 286 2022 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal preaxial LRD 4 0 0 1 5 46779 1.1 0.3 2.5 0 0 0 0 5 1.1 0.3 2.5 46603 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46779 46603 287 2022 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal postaxial LRD 1 0 0 0 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 288 2022 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal central LRD 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 289 2022 S92000003 Limb conditions Limb reduction defects (LRD) Intercalary LRD 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 290 2022 S92000003 Limb conditions Club foot/talipes equinovarus Club foot/talipes equinovarus 38 1 0 5 44 46779 9.4 6.8 12.6 4 0.9 0.2 2.2 40 8.6 6.1 11.6 46603 8.2 5.8 11.2 3 0.6 0.1 1.9 35 7.5 5.2 10.4 46779 46603 291 2022 S92000003 Limb conditions Hip dislocation Hip dislocation 9 0 0 0 9 46779 1.9 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 46603 1.9 0.9 3.7 2 0.4 0 1.6 7 1.5 0.6 3.1 46779 46603 292 2022 S92000003 Limb conditions Polydactyly Polydactyly 51 0 0 9 60 46779 12.8 9.8 16.5 7 1.5 0.6 3.1 53 11.3 8.5 14.8 46603 10.9 8.1 14.4 1 0.2 0 1.2 50 10.7 8 14.1 46779 46603 293 2022 S92000003 Limb conditions Syndactyly Syndactyly 12 0 0 3 15 46779 3.2 1.8 5.3 5 1.1 0.3 2.5 10 2.1 1 3.9 46603 2.6 1.3 4.5 3 0.6 0.1 1.9 9 1.9 0.9 3.7 46779 46603 294 2022 S92000003 Other conditions/syndromes Craniosynostosis Craniosynostosis 14 0 0 1 15 46779 3.2 1.8 5.3 3 0.6 0.1 1.9 12 2.6 1.3 4.5 46603 3 1.6 5 3 0.6 0.1 1.9 11 2.4 1.2 4.2 46779 46603 295 2022 S92000003 Other conditions/syndromes Congenital constriction band / Amniotic band sequence resulting in major congenital condition Congenital constriction band / Amniotic band sequence resulting in major congenital condition 1 0 0 3 4 46779 0.9 0.2 2.2 0 0 0 0 4 0.9 0.2 2.2 46603 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46779 46603 296 2022 S92000003 Other conditions/syndromes Situs inversus Situs inversus 2 0 0 1 3 46779 0.6 0.1 1.9 0 0 0 0 3 0.6 0.1 1.9 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 297 2022 S92000003 Other conditions/syndromes Conjoined twins Conjoined twins 0 0 0 1 1 46779 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 298 2022 S92000003 Other conditions/syndromes VATER/VACTERL association VATER/VACTERL association 8 0 0 2 10 46779 2.1 1 3.9 0 0 0 0 10 2.1 1 3.9 46603 1.7 0.7 3.4 0 0 0 0 8 1.7 0.7 3.4 46779 46603 299 2022 S92000003 Other conditions/syndromes Pierre-Robin sequence Pierre-Robin sequence 10 0 0 0 10 46779 2.1 1 3.9 1 0.2 0 1.2 9 1.9 0.9 3.7 46603 2.1 1 4 1 0.2 0 1.2 9 1.9 0.9 3.7 46779 46603 300 2022 S92000003 Other conditions/syndromes Caudal regression sequence Caudal regression sequence 2 0 0 0 2 46779 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46603 0.4 0 1.6 0 0 0 0 2 0.4 0 1.6 46779 46603 301 2022 S92000003 Other conditions/syndromes Sirenomelia Sirenomelia 0 0 0 3 3 46779 0.6 0.1 1.9 0 0 0 0 3 0.6 0.1 1.9 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 302 2022 S92000003 Other conditions/syndromes Septo-optic dysplasia Septo-optic dysplasia 1 0 0 0 1 46779 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46603 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 46779 46603 303 2022 S92000003 Other conditions/syndromes Vascular disruption conditions Vascular disruption conditions 22 0 0 9 31 46779 6.6 4.5 9.4 0 0 0 0 31 6.6 4.5 9.4 46603 4.7 3 7.1 0 0 0 0 22 4.7 3 7.1 46779 46603 304 2022 S92000003 Other conditions/syndromes Laterality conditions Laterality conditions 12 1 0 4 17 46779 3.6 2.1 5.8 2 0.4 0 1.6 15 3.2 1.8 5.3 46603 2.6 1.3 4.5 2 0.4 0 1.6 10 2.1 1 4 46779 46603 305 2022 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Teratogenic syndromes resulting in major congenital conditions 4 0 0 0 4 46779 0.9 0.2 2.2 2 0.4 0 1.6 2 0.4 0 1.6 46603 0.9 0.2 2.2 2 0.4 0 1.6 2 0.4 0 1.6 46779 46603 306 2022 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Valproate syndrome 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 307 2022 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Maternal infections resulting in major malformation 0 0 0 0 0 46779 0 0 0 0 0 0 0 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 308 2022 S92000003 Genetic conditions Genetic conditions Genetic conditions 139 13 4 174 330 46779 70.5 63.1 78.6 330 70.5 63.1 78.6 0 0 0 0 46603 29.8 25.1 35.2 139 29.8 25.1 35.2 0 0 0 0 46779 46603 309 2022 S92000003 Genetic conditions Skeletal dysplasias Skeletal dysplasias 10 0 0 8 18 46779 3.8 2.3 6.1 18 3.8 2.3 6.1 0 0 0 0 46603 2.1 1 4 10 2.1 1 4 0 0 0 0 46779 46603 310 2022 S92000003 Genetic conditions Skeletal dysplasias Severe skeletal dysplasias 3 0 0 5 8 46779 1.7 0.7 3.4 8 1.7 0.7 3.4 0 0 0 0 46603 0.6 0.1 1.9 3 0.6 0.1 1.9 0 0 0 0 46779 46603 311 2022 S92000003 Genetic conditions Down syndrome / trisomy 21 Down syndrome / trisomy 21 54 7 0 79 140 46779 29.9 25.2 35.3 140 29.9 25.2 35.3 0 0 0 0 46603 11.6 8.7 15.1 54 11.6 8.7 15.1 0 0 0 0 46779 46603 312 2022 S92000003 Genetic conditions Patau syndrome / trisomy 13 Patau syndrome / trisomy 13 0 0 1 19 20 46779 4.3 2.6 6.6 20 4.3 2.6 6.6 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 313 2022 S92000003 Genetic conditions Edwards syndrome / trisomy 18 Edwards syndrome / trisomy 18 3 2 1 35 41 46779 8.8 6.3 11.9 41 8.8 6.3 11.9 0 0 0 0 46603 0.6 0.1 1.9 3 0.6 0.1 1.9 0 0 0 0 46779 46603 314 2022 S92000003 Genetic conditions Turner syndrome / monosomy X Turner syndrome / monosomy X 0 0 1 12 13 46779 2.8 1.5 4.8 13 2.8 1.5 4.8 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 315 2022 S92000003 Genetic conditions Triploidy and polyploidy Triploidy and polyploidy 0 0 1 4 5 46779 1.1 0.3 2.5 5 1.1 0.3 2.5 0 0 0 0 46603 0 0 0 0 0 0 0 0 0 0 0 46779 46603 316 2021 S92000003 All conditions All conditions All conditions 857 23 5 301 1186 48307 245.5 231.7 259.9 306 63.3 56.5 70.9 880 182.2 170.3 194.6 48124 178.1 166.4 190.4 134 27.8 23.3 33 723 150.2 139.5 161.6 48307 48124 317 2021 S92000003 Nervous system conditions Nervous system conditions Nervous system conditions 58 6 0 88 152 48307 31.5 26.7 36.9 21 4.3 2.7 6.6 131 27.1 22.7 32.2 48124 12.1 9.2 15.6 9 1.9 0.9 3.6 49 10.2 7.5 13.5 48307 48124 318 2021 S92000003 Nervous system conditions Neural Tube Defects Neural Tube Defects 12 4 0 52 68 48307 14.1 10.9 17.8 2 0.4 0 1.5 66 13.7 10.6 17.4 48124 2.5 1.3 4.4 0 0 0 0 12 2.5 1.3 4.4 48307 48124 319 2021 S92000003 Nervous system conditions Neural Tube Defects Anencephaly and similar 1 3 0 31 35 48307 7.2 5 10.1 2 0.4 0 1.5 33 6.8 4.7 9.6 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 320 2021 S92000003 Nervous system conditions Neural Tube Defects Encephalocele and meningocele 1 0 0 4 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 321 2021 S92000003 Nervous system conditions Neural Tube Defects Spina Bifida 10 1 0 17 28 48307 5.8 3.9 8.4 0 0 0 0 28 5.8 3.9 8.4 48124 2.1 1 3.8 0 0 0 0 10 2.1 1 3.8 48307 48124 322 2021 S92000003 Nervous system conditions Hydrocephalus Hydrocephalus 19 1 0 13 33 48307 6.8 4.7 9.6 7 1.4 0.6 3 26 5.4 3.5 7.9 48124 3.9 2.4 6.2 4 0.8 0.2 2.1 15 3.1 1.7 5.1 48307 48124 323 2021 S92000003 Nervous system conditions Severe microcephaly Severe microcephaly 7 1 0 2 10 48307 2.1 1 3.8 3 0.6 0.1 1.8 7 1.4 0.6 3 48124 1.5 0.6 3 2 0.4 0 1.5 5 1 0.3 2.4 48307 48124 324 2021 S92000003 Nervous system conditions Arhinencephaly / holoprosencephaly Arhinencephaly / holoprosencephaly 3 0 0 7 10 48307 2.1 1 3.8 3 0.6 0.1 1.8 7 1.4 0.6 3 48124 0.6 0.1 1.8 1 0.2 0 1.2 2 0.4 0 1.5 48307 48124 325 2021 S92000003 Nervous system conditions Agenesis of corpus callosum Agenesis of corpus callosum 4 0 0 2 6 48307 1.2 0.4 2.7 2 0.4 0 1.5 4 0.8 0.2 2.1 48124 0.8 0.2 2.1 1 0.2 0 1.2 3 0.6 0.1 1.8 48307 48124 326 2021 S92000003 Eye conditions Eye conditions Eye conditions 28 0 0 0 28 48307 5.8 3.9 8.4 10 2.1 1 3.8 18 3.7 2.2 5.9 48124 5.8 3.9 8.4 10 2.1 1 3.8 18 3.7 2.2 5.9 48307 48124 327 2021 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos / microphthalmos 4 0 0 0 4 48307 0.8 0.2 2.1 3 0.6 0.1 1.8 1 0.2 0 1.2 48124 0.8 0.2 2.1 3 0.6 0.1 1.8 1 0.2 0 1.2 48307 48124 328 2021 S92000003 Eye conditions Anophthalmos / microphthalmos Anophthalmos 1 0 0 0 1 48307 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 48124 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 48307 48124 329 2021 S92000003 Eye conditions Congenital cataract Congenital cataract 10 0 0 0 10 48307 2.1 1 3.8 4 0.8 0.2 2.1 6 1.2 0.4 2.7 48124 2.1 1 3.8 4 0.8 0.2 2.1 6 1.2 0.5 2.7 48307 48124 330 2021 S92000003 Eye conditions Congenital glaucoma Congenital glaucoma 1 0 0 0 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 331 2021 S92000003 Ear, face and neck conditions Ear, face and neck conditions Ear, face and neck conditions 8 0 0 0 8 48307 1.7 0.7 3.3 2 0.4 0 1.5 6 1.2 0.4 2.7 48124 1.7 0.7 3.3 2 0.4 0 1.5 6 1.2 0.5 2.7 48307 48124 332 2021 S92000003 Ear, face and neck conditions Anotia and atresia/stenosis/stricture of external auditory canal Anotia and atresia/stenosis/stricture of external auditory canal 3 0 0 0 3 48307 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 333 2021 S92000003 Congenital heart disease (CHD) Congenital heart disease (CHD) Congenital heart disease (CHD) 273 6 1 66 346 48307 71.6 64.3 79.6 79 16.4 12.9 20.4 267 55.3 48.8 62.3 48124 56.7 50.2 63.9 46 9.6 7 12.7 227 47.2 41.2 53.7 48307 48124 334 2021 S92000003 Congenital heart disease (CHD) Severe CHD Severe CHD 91 5 0 41 137 48307 28.4 23.8 33.5 38 7.9 5.6 10.8 99 20.5 16.7 24.9 48124 18.9 15.2 23.2 20 4.2 2.5 6.4 71 14.8 11.5 18.6 48307 48124 335 2021 S92000003 Congenital heart disease (CHD) Severe CHD Common arterial truncus 5 0 0 3 8 48307 1.7 0.7 3.3 5 1 0.3 2.4 3 0.6 0.1 1.8 48124 1 0.3 2.4 3 0.6 0.1 1.8 2 0.4 0 1.5 48307 48124 336 2021 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet right ventricle 3 0 0 4 7 48307 1.4 0.6 3 2 0.4 0 1.5 5 1 0.3 2.4 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 337 2021 S92000003 Congenital heart disease (CHD) Severe CHD Double outlet left ventricle 1 0 0 0 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 338 2021 S92000003 Congenital heart disease (CHD) Severe CHD Complete transposition of great arteries (D-TGA) 11 1 0 2 14 48307 2.9 1.6 4.9 2 0.4 0 1.5 12 2.5 1.3 4.3 48124 2.3 1.1 4.1 1 0.2 0 1.2 10 2.1 1 3.8 48307 48124 339 2021 S92000003 Congenital heart disease (CHD) Severe CHD Single ventricle 0 0 0 1 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 340 2021 S92000003 Congenital heart disease (CHD) Severe CHD Corrected transposition of great arteries (L-TGA) 2 0 0 1 3 48307 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48124 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48307 48124 341 2021 S92000003 Congenital heart disease (CHD) Severe CHD Atrioventricular septal defect (AVSD) 12 1 0 12 25 48307 5.2 3.3 7.6 15 3.1 1.7 5.1 10 2.1 1 3.8 48124 2.5 1.3 4.4 7 1.5 0.6 3 5 1 0.3 2.4 48307 48124 342 2021 S92000003 Congenital heart disease (CHD) Severe CHD Tetralogy and pentalogy of Fallot 17 2 0 4 23 48307 4.8 3 7.1 4 0.8 0.2 2.1 19 3.9 2.4 6.1 48124 3.5 2.1 5.7 2 0.4 0 1.5 15 3.1 1.7 5.1 48307 48124 343 2021 S92000003 Congenital heart disease (CHD) Severe CHD Pulmonary valve atresia 6 0 0 0 6 48307 1.2 0.4 2.7 0 0 0 0 6 1.2 0.4 2.7 48124 1.2 0.5 2.7 0 0 0 0 6 1.2 0.5 2.7 48307 48124 344 2021 S92000003 Congenital heart disease (CHD) Severe CHD Triscuspid atresia and stenosis 3 1 0 2 6 48307 1.2 0.4 2.7 0 0 0 0 6 1.2 0.4 2.7 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 345 2021 S92000003 Congenital heart disease (CHD) Severe CHD Ebstein's anomaly 3 1 0 1 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 346 2021 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic right heart (HRH/HRHS) 1 0 0 1 2 48307 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 347 2021 S92000003 Congenital heart disease (CHD) Severe CHD Aortic valve atresia/stenosis 4 0 0 1 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48307 48124 348 2021 S92000003 Congenital heart disease (CHD) Severe CHD Mitral valve atresia/stenosis 0 0 0 1 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 349 2021 S92000003 Congenital heart disease (CHD) Severe CHD Hypoplastic left heart (HLH/HLHS) 5 0 0 7 12 48307 2.5 1.3 4.3 3 0.6 0.1 1.8 9 1.9 0.8 3.5 48124 1 0.3 2.4 1 0.2 0 1.2 4 0.8 0.2 2.1 48307 48124 350 2021 S92000003 Congenital heart disease (CHD) Severe CHD Coarctation of aorta 15 0 0 2 17 48307 3.5 2 5.6 4 0.8 0.2 2.1 13 2.7 1.4 4.6 48124 3.1 1.7 5.1 3 0.6 0.1 1.8 12 2.5 1.3 4.4 48307 48124 351 2021 S92000003 Congenital heart disease (CHD) Severe CHD Aortic atresia/interrupted aortic arch 2 0 0 2 4 48307 0.8 0.2 2.1 2 0.4 0 1.5 2 0.4 0 1.5 48124 0.4 0 1.5 1 0.2 0 1.2 1 0.2 0 1.2 48307 48124 352 2021 S92000003 Congenital heart disease (CHD) Severe CHD Total anomalous pulmonary venous return 4 0 0 0 4 48307 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48124 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48307 48124 353 2021 S92000003 Congenital heart disease (CHD) Ventricular septal defect (VSD) Ventricular septal defect (VSD) 136 2 0 20 158 48307 32.7 27.8 38.2 30 6.2 4.2 8.9 128 26.5 22.1 31.5 48124 28.3 23.7 33.4 19 3.9 2.4 6.2 117 24.3 20.1 29.1 48307 48124 354 2021 S92000003 Congenital heart disease (CHD) Atrial septal defect (ASD) Atrial septal defect (ASD) 61 0 0 1 62 48307 12.8 9.8 16.5 12 2.5 1.3 4.3 50 10.4 7.7 13.6 48124 12.7 9.7 16.3 11 2.3 1.1 4.1 50 10.4 7.7 13.7 48307 48124 355 2021 S92000003 Congenital heart disease (CHD) Pulmonary valve stenosis Pulmonary valve stenosis 20 0 0 2 22 48307 4.6 2.9 6.9 2 0.4 0 1.5 20 4.1 2.5 6.4 48124 4.2 2.5 6.4 2 0.4 0 1.5 18 3.7 2.2 5.9 48307 48124 356 2021 S92000003 Congenital heart disease (CHD) Patent ductus arteriosus (PDA) as only CHD in term infants Patent ductus arteriosus (PDA) as only CHD in term infants 11 0 0 0 11 48307 2.3 1.1 4.1 2 0.4 0 1.5 9 1.9 0.8 3.5 48124 2.3 1.1 4.1 2 0.4 0 1.5 9 1.9 0.9 3.6 48307 48124 357 2021 S92000003 Respiratory conditions Respiratory conditions Respiratory conditions 15 0 0 3 18 48307 3.7 2.2 5.9 6 1.2 0.4 2.7 12 2.5 1.3 4.3 48124 3.1 1.7 5.1 4 0.8 0.2 2.1 11 2.3 1.1 4.1 48307 48124 358 2021 S92000003 Respiratory conditions Choanal stenosis or atresia Choanal stenosis or atresia 6 0 0 1 7 48307 1.4 0.6 3 4 0.8 0.2 2.1 3 0.6 0.1 1.8 48124 1.2 0.5 2.7 3 0.6 0.1 1.8 3 0.6 0.1 1.8 48307 48124 359 2021 S92000003 Respiratory conditions Congenital pulmonary airway malformations (CPAM) Congenital pulmonary airway malformations (CPAM) 2 0 0 0 2 48307 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48124 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48307 48124 360 2021 S92000003 Oro-facial clefts Oro-facial clefts Oro-facial clefts 77 0 0 14 91 48307 18.8 15.2 23.1 19 3.9 2.4 6.1 72 14.9 11.7 18.8 48124 16 12.6 20 9 1.9 0.9 3.6 68 14.1 11 17.9 48307 48124 361 2021 S92000003 Oro-facial clefts Cleft lip with or without cleft palate Cleft lip with or without cleft palate 38 0 0 12 50 48307 10.4 7.7 13.6 12 2.5 1.3 4.3 38 7.9 5.6 10.8 48124 7.9 5.6 10.8 4 0.8 0.2 2.1 34 7.1 4.9 9.9 48307 48124 362 2021 S92000003 Oro-facial clefts Cleft palate without cleft lip Cleft palate without cleft lip 39 0 0 2 41 48307 8.5 6.1 11.5 7 1.4 0.6 3 34 7 4.9 9.8 48124 8.1 5.8 11.1 5 1 0.3 2.4 34 7.1 4.9 9.9 48307 48124 363 2021 S92000003 Gastro-intestinal conditions Gastro-intestinal conditions Gastro-intestinal conditions 87 4 0 22 113 48307 23.4 19.3 28.1 18 3.7 2.2 5.9 95 19.7 15.9 24 48124 18.1 14.5 22.3 12 2.5 1.3 4.4 75 15.6 12.3 19.5 48307 48124 364 2021 S92000003 Gastro-intestinal conditions Oesophageal atresia with or without trachea-oesophageal fistula Oesophageal atresia with or without trachea-oesophageal fistula 13 2 0 2 17 48307 3.5 2 5.6 0 0 0 0 17 3.5 2 5.6 48124 2.7 1.4 4.6 0 0 0 0 13 2.7 1.4 4.6 48307 48124 365 2021 S92000003 Gastro-intestinal conditions Duodenal atresia or stenosis Duodenal atresia or stenosis 12 0 0 0 12 48307 2.5 1.3 4.3 4 0.8 0.2 2.1 8 1.7 0.7 3.3 48124 2.5 1.3 4.4 4 0.8 0.2 2.1 8 1.7 0.7 3.3 48307 48124 366 2021 S92000003 Gastro-intestinal conditions Atresia or stenosis of other parts of small intestine Atresia or stenosis of other parts of small intestine 5 0 0 0 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48307 48124 367 2021 S92000003 Gastro-intestinal conditions Ano-rectal atresia or stenosis Ano-rectal atresia or stenosis 18 0 0 6 24 48307 5 3.2 7.4 1 0.2 0 1.2 23 4.8 3 7.1 48124 3.7 2.2 5.9 1 0.2 0 1.2 17 3.5 2.1 5.7 48307 48124 368 2021 S92000003 Gastro-intestinal conditions Hirschsprung's disease Hirschsprung's disease 6 0 0 0 6 48307 1.2 0.4 2.7 0 0 0 0 6 1.2 0.4 2.7 48124 1.2 0.5 2.7 0 0 0 0 6 1.2 0.5 2.7 48307 48124 369 2021 S92000003 Gastro-intestinal conditions Atresia of bile ducts Atresia of bile ducts 4 0 0 0 4 48307 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48124 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48307 48124 370 2021 S92000003 Gastro-intestinal conditions Annular pancreas Annular pancreas 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 371 2021 S92000003 Gastro-intestinal conditions Anomalies of intestinal fixation Anomalies of intestinal fixation 10 0 0 3 13 48307 2.7 1.4 4.6 3 0.6 0.1 1.8 10 2.1 1 3.8 48124 2.1 1 3.8 2 0.4 0 1.5 8 1.7 0.7 3.3 48307 48124 372 2021 S92000003 Gastro-intestinal conditions Diaphragmatic hernia Diaphragmatic hernia 12 2 0 6 20 48307 4.1 2.5 6.4 4 0.8 0.2 2.1 16 3.3 1.9 5.4 48124 2.5 1.3 4.4 3 0.6 0.1 1.8 9 1.9 0.9 3.6 48307 48124 373 2021 S92000003 Abdominal wall defects Abdominal wall defects Abdominal wall defects 21 2 0 17 40 48307 8.3 5.9 11.3 4 0.8 0.2 2.1 36 7.5 5.2 10.3 48124 4.4 2.7 6.7 1 0.2 0 1.2 20 4.2 2.5 6.4 48307 48124 374 2021 S92000003 Abdominal wall defects Gastroschisis Gastroschisis 15 1 0 1 17 48307 3.5 2 5.6 0 0 0 0 17 3.5 2 5.6 48124 3.1 1.7 5.1 0 0 0 0 15 3.1 1.7 5.1 48307 48124 375 2021 S92000003 Abdominal wall defects Omphalocele Omphalocele 6 1 0 9 16 48307 3.3 1.9 5.4 3 0.6 0.1 1.8 13 2.7 1.4 4.6 48124 1.2 0.5 2.7 1 0.2 0 1.2 5 1 0.3 2.4 48307 48124 376 2021 S92000003 Kidney and urinary tract conditions Kidney and urinary tract conditions Kidney and urinary tract conditions 102 0 1 32 135 48307 27.9 23.4 33.1 8 1.7 0.7 3.3 127 26.3 21.9 31.3 48124 21.2 17.3 25.7 4 0.8 0.2 2.1 98 20.4 16.5 24.8 48307 48124 377 2021 S92000003 Kidney and urinary tract conditions Unilateral renal agenesis Unilateral renal agenesis 13 0 0 5 18 48307 3.7 2.2 5.9 3 0.6 0.1 1.8 15 3.1 1.7 5.1 48124 2.7 1.4 4.6 2 0.4 0 1.5 11 2.3 1.1 4.1 48307 48124 378 2021 S92000003 Kidney and urinary tract conditions Bilateral renal agenesis including Potter sequence Bilateral renal agenesis including Potter sequence 0 0 0 11 11 48307 2.3 1.1 4.1 1 0.2 0 1.2 10 2.1 1 3.8 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 379 2021 S92000003 Kidney and urinary tract conditions Multicystic renal dysplasia Multicystic renal dysplasia 15 0 0 4 19 48307 3.9 2.4 6.1 1 0.2 0 1.2 18 3.7 2.2 5.9 48124 3.1 1.7 5.1 1 0.2 0 1.2 14 2.9 1.6 4.9 48307 48124 380 2021 S92000003 Kidney and urinary tract conditions Congenital hydronephrosis including ureter obstruction Congenital hydronephrosis including ureter obstruction 44 0 0 4 48 48307 9.9 7.3 13.2 1 0.2 0 1.2 47 9.7 7.2 12.9 48124 9.1 6.6 12.3 1 0.2 0 1.2 43 8.9 6.5 12 48307 48124 381 2021 S92000003 Kidney and urinary tract conditions Lobulated, fused and horseshoe kidney and ectopic kidney Lobulated, fused and horseshoe kidney and ectopic kidney 13 0 0 1 14 48307 2.9 1.6 4.9 1 0.2 0 1.2 13 2.7 1.4 4.6 48124 2.7 1.4 4.6 0 0 0 0 13 2.7 1.4 4.6 48307 48124 382 2021 S92000003 Kidney and urinary tract conditions Bladder exstrophy and/or epispadias Bladder exstrophy and/or epispadias 3 0 0 0 3 48307 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 383 2021 S92000003 Kidney and urinary tract conditions Posterior urethral valves Posterior urethral valves 12 0 0 0 12 48307 2.5 1.3 4.3 0 0 0 0 12 2.5 1.3 4.3 48124 2.5 1.3 4.4 0 0 0 0 12 2.5 1.3 4.4 48307 48124 384 2021 S92000003 Kidney and urinary tract conditions Prune belly syndrome Prune belly syndrome 0 0 0 5 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 385 2021 S92000003 Genital conditions Genital conditions Genital conditions 99 0 0 1 100 48307 20.7 16.8 25.2 3 0.6 0.1 1.8 97 20.1 16.3 24.5 48124 20.6 16.7 25 2 0.4 0 1.5 97 20.2 16.3 24.6 48307 48124 386 2021 S92000003 Genital conditions Hypospadias Hypospadias 82 0 0 0 82 48307 17 13.5 21.1 2 0.4 0 1.5 80 16.6 13.1 20.6 48124 17 13.6 21.1 2 0.4 0 1.5 80 16.6 13.2 20.7 48307 48124 387 2021 S92000003 Genital conditions Indeterminate sex Indeterminate sex 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 388 2021 S92000003 Limb conditions Limb conditions Limb conditions 122 0 0 26 148 48307 30.6 25.9 36 19 3.9 2.4 6.1 129 26.7 22.3 31.7 48124 25.4 21.1 30.3 11 2.3 1.1 4.1 111 23.1 19 27.8 48307 48124 389 2021 S92000003 Limb conditions Limb reduction defects (LRD) Limb reduction defects (LRD) 13 0 0 9 22 48307 4.6 2.9 6.9 4 0.8 0.2 2.1 18 3.7 2.2 5.9 48124 2.7 1.4 4.6 1 0.2 0 1.2 12 2.5 1.3 4.4 48307 48124 390 2021 S92000003 Limb conditions Limb reduction defects (LRD) Transverse LRD 0 0 0 2 2 48307 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 391 2021 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal preaxial LRD 7 0 0 4 11 48307 2.3 1.1 4.1 2 0.4 0 1.5 9 1.9 0.8 3.5 48124 1.5 0.6 3 0 0 0 0 7 1.5 0.6 3 48307 48124 392 2021 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal postaxial LRD 2 0 0 2 4 48307 0.8 0.2 2.1 2 0.4 0 1.5 2 0.4 0 1.5 48124 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48307 48124 393 2021 S92000003 Limb conditions Limb reduction defects (LRD) Longitudinal central LRD 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 394 2021 S92000003 Limb conditions Limb reduction defects (LRD) Intercalary LRD 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 395 2021 S92000003 Limb conditions Club foot/talipes equinovarus Club foot/talipes equinovarus 31 0 0 6 37 48307 7.7 5.4 10.6 2 0.4 0 1.5 35 7.2 5 10.1 48124 6.4 4.4 9.1 1 0.2 0 1.2 30 6.2 4.2 8.9 48307 48124 396 2021 S92000003 Limb conditions Hip dislocation Hip dislocation 17 0 0 0 17 48307 3.5 2 5.6 0 0 0 0 17 3.5 2 5.6 48124 3.5 2.1 5.7 0 0 0 0 17 3.5 2.1 5.7 48307 48124 397 2021 S92000003 Limb conditions Polydactyly Polydactyly 46 0 0 4 50 48307 10.4 7.7 13.6 4 0.8 0.2 2.1 46 9.5 7 12.7 48124 9.6 7 12.7 3 0.6 0.1 1.8 43 8.9 6.5 12 48307 48124 398 2021 S92000003 Limb conditions Syndactyly Syndactyly 10 0 0 1 11 48307 2.3 1.1 4.1 1 0.2 0 1.2 10 2.1 1 3.8 48124 2.1 1 3.8 0 0 0 0 10 2.1 1 3.8 48307 48124 399 2021 S92000003 Other conditions/syndromes Craniosynostosis Craniosynostosis 16 0 0 0 16 48307 3.3 1.9 5.4 2 0.4 0 1.5 14 2.9 1.6 4.9 48124 3.3 1.9 5.4 2 0.4 0 1.5 14 2.9 1.6 4.9 48307 48124 400 2021 S92000003 Other conditions/syndromes Congenital constriction band / Amniotic band sequence resulting in major congenital condition Congenital constriction band / Amniotic band sequence resulting in major congenital condition 0 0 0 1 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 401 2021 S92000003 Other conditions/syndromes Situs inversus Situs inversus 2 0 0 1 3 48307 0.6 0.1 1.8 2 0.4 0 1.5 1 0.2 0 1.2 48124 0.4 0 1.5 1 0.2 0 1.2 1 0.2 0 1.2 48307 48124 402 2021 S92000003 Other conditions/syndromes Conjoined twins Conjoined twins 0 0 0 2 2 48307 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 403 2021 S92000003 Other conditions/syndromes VATER/VACTERL association VATER/VACTERL association 5 0 0 3 8 48307 1.7 0.7 3.3 0 0 0 0 8 1.7 0.7 3.3 48124 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48307 48124 404 2021 S92000003 Other conditions/syndromes Pierre-Robin sequence Pierre-Robin sequence 10 0 0 0 10 48307 2.1 1 3.8 1 0.2 0 1.2 9 1.9 0.8 3.5 48124 2.1 1 3.8 1 0.2 0 1.2 9 1.9 0.9 3.6 48307 48124 405 2021 S92000003 Other conditions/syndromes Caudal regression sequence Caudal regression sequence 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 406 2021 S92000003 Other conditions/syndromes Sirenomelia Sirenomelia 0 0 0 2 2 48307 0.4 0 1.5 0 0 0 0 2 0.4 0 1.5 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 407 2021 S92000003 Other conditions/syndromes Septo-optic dysplasia Septo-optic dysplasia 1 0 0 0 1 48307 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48124 0.2 0 1.2 0 0 0 0 1 0.2 0 1.2 48307 48124 408 2021 S92000003 Other conditions/syndromes Vascular disruption conditions Vascular disruption conditions 20 1 0 4 25 48307 5.2 3.3 7.6 0 0 0 0 25 5.2 3.3 7.6 48124 4.2 2.5 6.4 0 0 0 0 20 4.2 2.5 6.4 48307 48124 409 2021 S92000003 Other conditions/syndromes Laterality conditions Laterality conditions 5 1 0 3 9 48307 1.9 0.8 3.5 4 0.8 0.2 2.1 5 1 0.3 2.4 48124 1 0.3 2.4 1 0.2 0 1.2 4 0.8 0.2 2.1 48307 48124 410 2021 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Teratogenic syndromes resulting in major congenital conditions 4 1 0 0 5 48307 1 0.3 2.4 0 0 0 0 5 1 0.3 2.4 48124 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48307 48124 411 2021 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Valproate syndrome 0 0 0 0 0 48307 0 0 0 0 0 0 0 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124 412 2021 S92000003 Other conditions/syndromes Teratogenic syndromes resulting in major congenital conditions Maternal infections resulting in major malformation 3 1 0 0 4 48307 0.8 0.2 2.1 0 0 0 0 4 0.8 0.2 2.1 48124 0.6 0.1 1.8 0 0 0 0 3 0.6 0.1 1.8 48307 48124 413 2021 S92000003 Genetic conditions Genetic conditions Genetic conditions 134 10 3 159 306 48307 63.3 56.5 70.9 306 63.3 56.5 70.9 0 0 0 0 48124 27.8 23.3 33 134 27.8 23.3 33 0 0 0 0 48307 48124 414 2021 S92000003 Genetic conditions Skeletal dysplasias Skeletal dysplasias 10 2 0 9 21 48307 4.3 2.7 6.6 21 4.3 2.7 6.6 0 0 0 0 48124 2.1 1 3.8 10 2.1 1 3.8 0 0 0 0 48307 48124 415 2021 S92000003 Genetic conditions Skeletal dysplasias Severe skeletal dysplasias 2 1 0 5 8 48307 1.7 0.7 3.3 8 1.7 0.7 3.3 0 0 0 0 48124 0.4 0 1.5 2 0.4 0 1.5 0 0 0 0 48307 48124 416 2021 S92000003 Genetic conditions Down syndrome / trisomy 21 Down syndrome / trisomy 21 52 3 2 65 122 48307 25.3 21 30.2 122 25.3 21 30.2 0 0 0 0 48124 10.8 8.1 14.2 52 10.8 8.1 14.2 0 0 0 0 48307 48124 417 2021 S92000003 Genetic conditions Patau syndrome / trisomy 13 Patau syndrome / trisomy 13 3 0 0 20 23 48307 4.8 3 7.1 23 4.8 3 7.1 0 0 0 0 48124 0.6 0.1 1.8 3 0.6 0.1 1.8 0 0 0 0 48307 48124 418 2021 S92000003 Genetic conditions Edwards syndrome / trisomy 18 Edwards syndrome / trisomy 18 3 2 0 28 33 48307 6.8 4.7 9.6 33 6.8 4.7 9.6 0 0 0 0 48124 0.6 0.1 1.8 3 0.6 0.1 1.8 0 0 0 0 48307 48124 419 2021 S92000003 Genetic conditions Turner syndrome / monosomy X Turner syndrome / monosomy X 1 0 1 12 14 48307 2.9 1.6 4.9 14 2.9 1.6 4.9 0 0 0 0 48124 0.2 0 1.2 1 0.2 0 1.2 0 0 0 0 48307 48124 420 2021 S92000003 Genetic conditions Triploidy and polyploidy Triploidy and polyploidy 0 0 0 5 5 48307 1 0.3 2.4 5 1 0.3 2.4 0 0 0 0 48124 0 0 0 0 0 0 0 0 0 0 0 48307 48124